Pharmaceutical chitosan hydrogels: A review on its design and applications

Chellathurai, Melbha Starlin; Chung, Lip Yong; Hilles, Ayah R.; Sofian, Zarif Mohamed; Singha, Souvik; Ghosal, Kajal; Mahmood, Syed

doi:10.1016/j.ijbiomac.2024.135775

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.135775

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Pharmaceutical chitosan hydrogels: A review on its design and applications

Melbha Starlin Chellathurai,

Lip Yong Chung,

Ayah R. Hilles

et al.

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Cited by 2 publications

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Influence of agarose in semi-IPN hydrogels for sustained Polymyxin B release

Filho,

Guerrero,

Castro

et al. 2025

Colloids and Surfaces B: Biointerfaces

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Influence of agarose in semi-IPN hydrogels for sustained Polymyxin B release

Filho,

Guerrero,

Castro

et al. 2025

Colloids and Surfaces B: Biointerfaces

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The Properties of Thin Films Based on Chitosan/Konjac Glucomannan Blends

Kulka-Kamińska,

Sionkowska

2024

Polymers

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In this work, blend films were prepared by blending 2% chitosan (CS) and 0.5% konjac glucomannan (KGM) solutions. Five ratios of the blend mixture were implemented (95:5, 80:20, 50:50, 20:80, and 5:95), and a pure CS film and a pure KGM film were also obtained. All the polymeric films were evaluated using FTIR spectroscopy, mechanical testing, SEM and AFM imaging, thermogravimetric analyses, swelling and degradation analyses, and contact angle measurements. The CS/KGM blends were assessed for their miscibility. Additionally, the blend films’ properties were evaluated after six months of storage. The proposed blends had good miscibility in a full range of composition proportions. The blend samples, compared to the pure CS film, indicated better structural integrity. The surface structure of the blend films was rather uniform and smooth. The sample CS/KGM 20:80 had the highest roughness value (Rq = 12.60 nm). The KGM addition increased the thermal stability of films. The blend sample CS/KGM 5:95 exhibited the greatest swelling ability, reaching a swelling degree of 946% in the first fifteen minutes of the analysis. Furthermore, the addition of KGM to CS improved the wettability of the film samples. As a result of their good mechanical properties, surface characteristics, and miscibility, the proposed CS/KGM blends are promising materials for topical biomedical and cosmetic applications.

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Pharmaceutical chitosan hydrogels: A review on its design and applications

Cited by 2 publications

References 72 publications

Influence of agarose in semi-IPN hydrogels for sustained Polymyxin B release

Influence of agarose in semi-IPN hydrogels for sustained Polymyxin B release

The Properties of Thin Films Based on Chitosan/Konjac Glucomannan Blends

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