2013
DOI: 10.5731/pdajpst.2013.00926
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Pharmaceutical Development of a Parenteral Formulation of Conivaptan Hydrochloride

Abstract: Formulation scientists have recognized a trend that promising new chemical entities in the drug discovery phase often do not have ideal physicochemical properties for formulation. In particular, poor solubility is one of the challenges for development of a parenteral dosage form. Here, we describe the case of such a new chemical entity, a very slightly soluble hydrochloric salt, which was handed over from a drug discovery research laboratory to a pharmaceutical laboratory. pH control and cosolvency techniques … Show more

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Cited by 6 publications
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