Pharmaceutical Efficacy of Artemisinin from Artemisia Pallens with Reference to Antitumor Potential

Abstract

This rapidly developing field of nanoscience has raised the possibility of using therapeutic nanoparticles in the diagnosis and treatment of human cancers. The research demonstrates the efficiency of artemisinin is a sesquiterpene lactone isolated from the leaves of Artemisia pallens by using classical biochemical techniques and the purified molecules analyzed by HPLC. The artemisinin concentration has been reported to be higher at the top of the leaves Artemisia pallens plants, shown to be effective against Dalton's lymphoma ascites (DLA) cancer. Carboplatin, a platinum-containing anticancer drug treatment caused a significant increase in the life span of ascites Dalton's lymphoma tumor bearing mice. However, as compared to carboplatin, artemisinin and combination treatment with artemisinin plus carboplatin resulted in better therapeutic efficacy against Dalton's lymphoma tumor. Artemisinin loaded silver nanoparticles were administrated to ascites Dalton's lymphoma tumor induced mice 100µg/kg/day IP injection for 15 days at two days intervals, the antitumor efficiency of AgNPs significantly increased the survival time in the tumor mouse model in comparison with tumor controls also decreased the volume of ascitic fluid in tumor-bearing mice by 75%, thereby returning body weight closer to normal animals. Artemisinin may be especially effective in treating drug resistant cancers. These findings confirm the antitumor properties of AgNPs, and suggest that bioactive substance Artemisinin may be a cost-effective alternative in the treatment of cancer.