Pharmaceutical-eluting hybrid degradable hydrogel/microparticle loaded sacs for finger joint interpositional arthroplasty

Hsu, Yung-Hen; Yu, Yi‐Hsun; Lee, Demei; Chou, Ying‐Chao; Wu, Chenkai; Lu, Chia Jung; Liu, Shih‐Jung

doi:10.1016/j.bioadv.2022.212846

Cited by 7 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal models have found that loaded hydrogels are able to achieve the MBEC for multiple common ODRI pathogens [ 126 ]. The forefront of hydrogel technology has produced layered microparticles within a hydrogel to enable multiphase release, in a rabbit model releasing vancomycin and ceftazidime at stable therapeutic level out to 56 days, while simultaneously administering lidocaine for pain relief to 14 days [ 127 ].…”

Section: Local Antibiotic Carriersmentioning

confidence: 99%

Local Antibiotic Delivery Options in Prosthetic Joint Infection

et al. 2023

View full text Add to dashboard Cite

Prosthetic Joint Infection (PJI) causes significant morbidity and mortality for patients globally. Delivery of antibiotics to the site of infection has potential to improve the treatment outcomes and enhance biofilm eradication. These antibiotics can be delivered using an intra-articular catheter or combined with a carrier substance to enhance pharmacokinetic properties. Carrier options include non-resorbable polymethylmethacrylate (PMMA) bone cement and resorbable calcium sulphate, hydroxyapatite, bioactive glass, and hydrogels. PMMA allows for creation of structural spacers used in multi-stage revision procedures, however it requires subsequent removal and antibiotic compatibility and the levels delivered are variable. Calcium sulphate is the most researched resorbable carrier in PJI, but is associated with wound leakage and hypercalcaemia, and clinical evidence for its effectiveness remains at the early stage. Hydrogels provide a versatile combability with antibiotics and adjustable elution profiles, but clinical usage is currently limited. Novel anti-biofilm therapies include bacteriophages which have been used successfully in small case series.

show abstract

Section: Local Antibiotic Carriersmentioning

confidence: 99%

Local Antibiotic Delivery Options in Prosthetic Joint Infection

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Among the various biodegradable polymers, poly(lacticco-glycolic acid) (PLGA) is the most extensively researched owing to its ability to reduce inflammatory effects in the tissue during hydrolytic degradation and its capacity for drug delivery [25][26][27]. The polymer-incorporated drug can be used for therapeutic purposes, such as chemotherapy or antimicrobial activity [28][29][30]. The reduced inflammatory process also diminishes the development of adhesions during the tissue's healing cascade [31].…”

Section: Introductionmentioning

confidence: 99%

Anti-Adhesive Resorbable Indomethacin/Bupivacaine-Eluting Nanofibers for Tendon Rupture Repair: In Vitro and In Vivo Studies

Yu,

Lee,

Hsu

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

The treatment and surgical repair of torn Achilles tendons seldom return the wounded tendon to its original elasticity and stiffness. This study explored the in vitro and in vivo simultaneous release of indomethacin and bupivacaine from electrospun polylactide–polyglycolide composite membranes for their capacity to repair torn Achilles tendons. These membranes were fabricated by mixing polylactide–polyglycolide/indomethacin, polylactide–polyglycolide/collagen, and polylactide–polyglycolide/bupivacaine with 1,1,1,3,3,3-hexafluoro-2-propanol into sandwich-structured composites. Subsequently, the in vitro pharmaceutic release rates over 30 days were determined, and the in vivo release behavior and effectiveness of the loaded drugs were assessed using an animal surgical model. High concentrations of indomethacin and bupivacaine were released for over four weeks. The released pharmaceutics resulted in complete recovery of rat tendons, and the nanofibrous composite membranes exhibited exceptional mechanical strength. Additionally, the anti-adhesion capacity of the developed membrane was confirmed. Using the electrospinning technique developed in this study, we plan on manufacturing degradable composite membranes for tendon healing, which can deliver sustained pharmaceutical release and provide a collagenous habitat.

show abstract

Electrospun Nanofibrous Composite Membranes for Long‐Term Release of Celecoxib for Achilles Tendon Reconstruction Following Injury

Lee

Hsu

et al. 2023

Macro Materials & Eng

View full text Add to dashboard Cite

Embedding multiple pharmaceutical drugs into poly(lactic‐co‐glycolic acid) (PLGA) nanofibers is known to improve the regeneration of the Achilles tendon upon implantation after injury and rapidly restore post‐surgery activity. In this study, an implantable material comprising celecoxib, collagen, bupivacaine, and PLGA (CCBP) is prepared by electrospinning. Its in vitro/vivo drug discharge behaviors are evaluated, and its efficacy in tendon regeneration is investigated in a rat model. The regeneration capacity of the wounded tendon is also compared with that of a doxycycline‐collagen‐bupivacaine‐PLGA (DCBP) combination. The results show that, relative to the primary PLGA nanofibers, the pharmaceutical‐embedded nanofibers have thinner fiber diameters and higher hydrophilicity. The drug‐eluting nanofibers also offer a sustained release of celecoxib for at least 30 d in vitro and 28 d in vivo. Achilles tendons regenerated using the CCBP combination nanofibers demonstrate a significantly higher maximum load‐to‐failure than normal tendons and those repaired using the DCBP combination. Additionally, the expression of growth factors and composition of collagen I induced by the CCBP combination are superior to those induced by the DCBP combination. The results suggest that the CCBP combination is a promising scaffold for the repair of ruptured Achilles tendons.

show abstract

Pharmaceutical-eluting hybrid degradable hydrogel/microparticle loaded sacs for finger joint interpositional arthroplasty

Cited by 7 publications

References 52 publications

Local Antibiotic Delivery Options in Prosthetic Joint Infection

Local Antibiotic Delivery Options in Prosthetic Joint Infection

Anti-Adhesive Resorbable Indomethacin/Bupivacaine-Eluting Nanofibers for Tendon Rupture Repair: In Vitro and In Vivo Studies

Electrospun Nanofibrous Composite Membranes for Long‐Term Release of Celecoxib for Achilles Tendon Reconstruction Following Injury

Contact Info

Product

Resources

About