Niruha Basti (decoction enema) has been given importance in classical texts of Ayurveda as well as is widely practiced by physicians as it can be given in patients of all ages and of all diseases. Basti formulation and administration greatly impact the therapeutic effects. The contents, their dosage, properties, order and method of mixing, characteristics of well-prepared Niruha Basti, rationality behind sequential mixing and need for Basti formulation should be studied thoroughly so as to understand the essence of science, to achieve desired therapeutic effects and to avoid complications. So, here is an attempt to understand the entire concept of Niruha Basti formulation with the help of references from classical texts, textbooks, previous articles on this topic from reputed journals.