Pharmaceutical Nano‐Cocrystals: Sonochemical Synthesis by Solvent Selection and Use of a Surfactant

Sander, John; Bučar, Dejan‐Krešimir; Henry, Rodger F.; Zhang, Geoff G. Z.; MacGillivray, Leonard R.

doi:10.1002/ange.201002588

Cited by 17 publications

(5 citation statements)

References 43 publications

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“…Interestingly, besides the spheres some other shapes such as 'spindle' (Figure 2d) and 'tadpole' (Figure 2e) with the same size were obtained, while these shapes were also constituted by nano-particles. In general, nanoparticles easily form aggregates due to the inherent character of high surface energy [31]. Additionally, for the nano-explosive crystal, particle growth by Ostwald ripening may happen in the storage process [32].…”

Section: Resultsmentioning

confidence: 99%

Facile Fabrication of Nanoparticles Stacked 2,6‐diamino‐3,5‐dinitropyrazine‐1‐oxide (LLM‐105) Sub‐microspheres via Electrospray Deposition

Huang

Liu

Ding

et al. 2017

Propellants Explo Pyrotec

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In this study, nanoparticles stacked 2,6‐diamino‐3,5‐dinitropyrazine‐1‐oxide (LLM‐105) sub‐microspheres were successfully fabricated by electrospray deposition. These monodisperse sub‐microspheres with a diameter from 200–500 nm are composed of 50 nm nanoparticles, and after preserved six months these spheres retain the same structure and morphology. The effect of process parameter including flow rate and nozzle size on the size and morphology of sub‐microsphere is investigated. The results show that, for a given solution concentration the nozzle size has little effect while the flow rate shows a significant effect. The X‐ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT‐IR) results exhibit that the as‐prepared sub‐microspheres have the same crystal and chemical structure as the raw materials. The thermal behavior performed by simultaneous thermal analysis (TG‐DSC) verifies that in comparison to the raw materials sub‐microspheres have a lower onset degradation temperature.

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Section: Resultsmentioning

confidence: 99%

Facile Fabrication of Nanoparticles Stacked 2,6‐diamino‐3,5‐dinitropyrazine‐1‐oxide (LLM‐105) Sub‐microspheres via Electrospray Deposition

Huang

Liu

Ding

et al. 2017

Propellants Explo Pyrotec

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“…Similarly, Sander et al 9 used a combination of multiple-solvents and surfactant to reduce noncongruency between caffeine and 2,4-dihydroxybenzoic acid in the presence of ultrasound to obtain cocrystals. High solubility of co-crystal components and use of surfactant was found to increase nucleation rate and form nano-co-crystals.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Caffeine/Maleic Acid Co-crystal by Ultrasound-assisted Slurry Co-crystallization

Apshingekar

Aher

Kelly

et al. 2017

Journal of Pharmaceutical Sciences

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ABSTRACT:A green approach has been used for co-crystallization of non-congruent co-crystal pair of caffeinemaleic acid using water. Ultrasound is known to affect crystallization hence the effect of high power ultrasound on the ternary phase diagram has been investigated in detail using a slurry co-crystallization approach. A systematic investigation was performed to understand how the accelerated conditions during ultrasound assisted co-crystallization will affect different regions of the ternary phase diagram.Application of ultrasound showed considerable effect on the ternary phase diagram; principally on caffeine/maleic acid 2:1 (disappeared) and 1:1 co-crystal (narrowed) regions. Also, the stability regions for pure caffeine and maleic acid in water were narrowed in the presence of ultrasound, expanding the solution region. The observed effect of ultrasound on the phase diagram was correlated with solubility of caffeine and maleic acid and stability of co-crystal forms in water.

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“…Great research efforts have been spent in order to tailor and improve the properties of EMs by adjusting or modifying substance compositions, controlling material morphology [74], reducing particle size [75], and synthesizing new materials [76]. Through the years, it has been observed in the field of material science that co-crystals have great potentials in various important applications by adjusting their crystal structure at the molecular level [77][78][79][80][81][82][83]. Note that by means of co-crystallization technology, the physico-chemical properties of two independent components can be efficiently combined and produced a modified material in the direction of amelioration of the properties.…”

Section: Some Cl-20 Based Energetic Cocrystals -A Reviewmentioning

confidence: 99%

Some CL-20 based energetic cocrystals - A review

Türker

2024

EJCS

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There exists an inherent contradiction between the energy density and safety of energetic materials. To ameliorate and get an accord between energy and safety, cocrystallization seems to be a remedy which has been getting quite popular in the field of energetic materials. Energetic cocrystals represent one of the most important classes of research advances in the area of energetic materials. The cocrystallization significantly improves performance of energetic cocrystals, such as density, solubility, sensitivity, and thermal stability. This mini review summaries some of CL-20 based energetic cocrystals in terms of various aspects of them.

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Pharmaceutical Nano‐Cocrystals: Sonochemical Synthesis by Solvent Selection and Use of a Surfactant

Cited by 17 publications

References 43 publications

Facile Fabrication of Nanoparticles Stacked 2,6‐diamino‐3,5‐dinitropyrazine‐1‐oxide (LLM‐105) Sub‐microspheres via Electrospray Deposition

Facile Fabrication of Nanoparticles Stacked 2,6‐diamino‐3,5‐dinitropyrazine‐1‐oxide (LLM‐105) Sub‐microspheres via Electrospray Deposition

Synthesis of Caffeine/Maleic Acid Co-crystal by Ultrasound-assisted Slurry Co-crystallization

Some CL-20 based energetic cocrystals - A review

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