Pharmaceutical Nanotechnology: Innovation and Production

Cornier, Jean; Owen, A. E. Tony; Kwade, Arno; Voorde, Marcel Van de

doi:10.1002/9783527800681

Cited by 16 publications

(21 citation statements)

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“…They include materials of various nature occurring as particles at the nanometer size scale (1-1000 nm) [6,18]. Although nanomedicines have the potential to revolutionize medicines, several challenges remain to be addressed to accelerate their translation to the clinic [19,20]. One of these challenges is the assessment of their quality and safety, which is closely linked to their physicochemical properties [21,22].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of zeta potential of nanomaterials by electrophoretic light scattering: Fast field reversal versus Slow field reversal modes

Varenne

Coty

Botton

et al. 2019

Talanta

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Zeta potential of nanomaterials designed to be used in nanomedecine is an important parameter to evaluate as it influences in vivo behaviour hence biological activity, efficacy and safety. As mentioned by the International Organization for Standardization (ISO), electrophoretic light scattering is a relevant method for evaluating zeta potential. The present work aimed to validate a new protocol based on the application of Fast Field Reversal mode and to explore its scope with nanomaterials investigated as nanomedicines. Its scope was then compared with that of an already validated protocol which uses both Fast Field Reversal and Slow Field Reversal modes. The new protocol was validated within the framework of the application of the Smoluchowski approximation. Its performances complied with the ISO standard. The protocol could be applied to evaluate mean zeta potential of soft nanomaterials including polymer-based nanomedicines and liposomes. However, it appeared unsuitable to evaluate zeta potential of dense nanomaterial including rutile titanium dioxide nanoparticles. Compared with the previously validated protocol which only applied to the determination of zeta potential of polymer nanoparticles, this new validated protocol gives access to the determination of zeta potential to a wider range of nanomedicines under conditions complying with quality control assessments.

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Section: Introductionmentioning

confidence: 99%

Evaluation of zeta potential of nanomaterials by electrophoretic light scattering: Fast field reversal versus Slow field reversal modes

Varenne

Coty

Botton

et al. 2019

Talanta

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“…Nanoparticles (NPs) have attracted a considerable attention due to their small size that confers the ability to be transported more easily through the body [2]. Several types of nanoparticles have been synthesized in recent years: (i) metal-based NPs (e.g., gold NPs, gold nano-rods, gold nano-shells, super-paramagnetic iron oxide NPs) [3], (ii) carbon-based NPs (e.g., graphene NPs, single-wall carbon nanotubes (CNTs) and multi-wall CNTs) [4], (iii) semiconductor-based NPs (cadmium selenide quantum dots (QDs), cadmium telluride QDs) [5], and (iv) soft matter-based NPs, including single-chain nanoparticles (SCNPs) formed via folding of individual polymer chains [6], among other ones.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Preliminary Evaluation of Povidone Single-Chain Nanoparticles as Potential Drug Delivery Nanocarriers

Asenjo-Sanz¹,

Del-Corte²,

Pinacho-Olaciregui³

et al. 2019

Med One

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One of the key areas in nanomedicine is the use of nanometer-sized materials as nanocarriers for therapeutic and diagnostic (theranostic) purposes. In particular, nanoparticles (NPs) have attracted a considerable attention due to their small size that confers the ability to be transported more easily through the body. Ideally, nanocarriers would be biocompatible and biodegradable so the involvement of soft matter-based NPs is an interesting approach. Folding individual polymer chains to single-chain nanoparticles (SCNPs) endows the resulting soft nano-objects with promising prospects for drug encapsulation and subsequent controlled delivery. In this work, we report on the preparation and preliminary (in vitro) evaluation of Povidone SCNPs as potential drug delivery nanocarriers. We select Povidone (polyvinylpyrrolidone) as a water-soluble polymer with a large commercial use in medicine, which is biocompatible and non-antigenic as well as safe for oral and topical applications. For evaluation of Povidone SCNPs as drug delivery nanocarriers, we select two drugs with reported anti-cancer activity: (i) Cisplatin, a widely used hydrophilic anticancer agent for treatment of a variety of cancer cells; and (ii) Lovastatin, a lipophilic compound with in vitro anti-proliferative, pro-apoptotic and anti-invasive effects in different cancer cell lines. After showing release of these drugs from Povidone SCNPs, we demonstrate that these nanoparticles can be rendered fluorescent in combination with functional aggregation-induced emission (AIE) fluorophore molecules paving the way to the potential development of theranostic Povidone SCNPs.

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“…Nanoemulsions which carry lipophilic drugs for intravenous, peroral and dermal administrations are commonly produced by high pressure homogenization [1,2]. Due to high pressure, high energy dissipation and high shear forces, temperatures are increased and sensitive substances, such as proteins, may suffer [3].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Nanoporous Superalloy Membranes for the Production of Nanoemulsions

Kohnke

Finke

Kwade

et al. 2018

Metals

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Premix membrane emulsification is a gentle process for producing nanoemulsions, i.e., for pharmaceutical purposes. The operating time of common membranes is short today, because of their fragility, membrane fouling and poor cleanability. In contrast, superalloy membranes are cleansable because of their high mechanical strength as well as high chemical and thermal resistances and therefore, could achieve clearly longer operating times. Their usability for premix membrane emulsification is investigated in this study. Different flow rates of the premix emulsion were tested up to 21 cycles with a small-scale extruder, three different nanoporous superalloy membrane structures have been tested in comparison to a common polymer membrane. Varying the two-phase-structure (γ-and γ-phase) of superalloy bulk material through thermal or thermo-mechanical treatments and chemical extraction of either one of the phases, different membrane microstructures could be obtained. These membranes differ in pore size, pore structure, and porosity, resulting in different flow resistances, droplet sizes and droplet size distributions in the investigated premix membrane emulsification process. Emulsions with droplet sizes in the desired range of 100 to 500 nm and with acceptable droplet size distributions were achieved. Data display an improved process stability for superalloy membranes, however, special attention needs to be paid towards narrow droplet size distributions.

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Pharmaceutical Nanotechnology: Innovation and Production

Cited by 16 publications

References 0 publications

Evaluation of zeta potential of nanomaterials by electrophoretic light scattering: Fast field reversal versus Slow field reversal modes

Evaluation of zeta potential of nanomaterials by electrophoretic light scattering: Fast field reversal versus Slow field reversal modes

Preparation and Preliminary Evaluation of Povidone Single-Chain Nanoparticles as Potential Drug Delivery Nanocarriers

Investigation of Nanoporous Superalloy Membranes for the Production of Nanoemulsions

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