Pharmaceutical properties of marine polyphenols: an overview

Abstract

The marine environment represents approximately half of the global biodiversity. It is a rich source of structurally diverse and biologically active metabolites, which are important for the discovery of potential therapeutic agents 1, 2. During the last decades, marine organisms have received much attention in screening marine natural products for their biomedical and pharmaceutical potentials 3-5. Various marine organisms such as algae, tunicates, sponges, soft ABSTRACT Natural products are non-drug materials that have applied for prevention or treatment of health problem. The use of natural products as pharmaceutical ingredients has got much attention by consumers nowadays. Among them, marine organisms are currently considered as a huge source for the discovery of pharmaceutical agents. During the last decades, numerous novel agents have been achieved from marine organisms and many of them have potential application in pharmaceutical industry. Notably, marine algae are known to be one of the most important producers of variety of chemically active metabolites. Especially, phlorotannins, a polyphenol from brown algae, have been revealed to possess numerous biological activities such as UV-protective, anti-oxidant, anti-viral, anti-allergic, anti-cancer, anti-inflammatory, anti-diabetes, and anti-obesity activities. Therefore, phlorotannins are promising agents for development of pharmaceutical products. This contribution focuses on phlorotannins from brown algae and presents potential application in pharmaceutical field due to its biological activities and health benefit effects.

Characteristics of Polyphenolic Content in Brown Algae of the Pacific Coast of Russia

“…Antioxidant effect is associated with polyphenols and particularly the phlorotannins, the oligomers or polymers of phloroglucinol [ 3 , 4 ]. They are considered to be found only in brown seaweed [ 5 , 6 ]. Antioxidant activity of phlorotannins, extracted from the different brown algae species, was demonstrated in vitro [ 7 , 8 ].…”

Antioxidant and antidiabetic activities of vanadium‐binding protein and trifuhalol A

“…The difference between VBP and protein‐vanadium complex might be because the former from sea squirt had the electron‐donating ability, while the latter lost the electron‐donating activity during the synthesis process. It has been reported that phlorotannins can inhibit the formation of free radicals and avoid the damage of cellular proteins, nucleic acids, and lipids caused by reactive oxygen (Kang et al, 2004; Sang et al, 2019). The previous studies displayed that the radical scavenging activity of phlorotannins were attributed to phlorotannins content and molecular weight, further study suggested that hydroxyl group availability in phlorotannins played a key role in determining phlorotannin antioxidant ability (Jacobsen et al, 2019).…”

“…The phenolic compound phlorotannins existed particularly in brown algae was found to have strong antioxidant, antimicrobial, anticancer, UV‐protective, anti‐HIV, anti‐Alzheimer, and anti‐inflammatory activities (Catarino et al, 2019; Phasanasophon & Kim, 2018; Sang et al, 2019). Agarum cribrosum, a common brown algae, mainly distributed in the subtidal areas in Northeast Asian countries, such as Korea, China, and Japan (Cho et al, 2014).…”

In Vitro and In Vivo Biocontrol of Tomato Fusarium Wilt by Extracts from Brown, Red, and Green Macroalgae

“…We believe this is because S. dentifolium extract had the highest total phenol content of the algae tested. Phenols and flavonoids can play important roles in inhibiting the growth of some microorganisms [49].…”