Pharmaceutical properties of 'sucupira' (Pterodon spp.)

Hansen, Daiane; Haraguchi, Mitsue; Alonso, Antônio

doi:10.1590/s1984-82502010000400002

Cited by 35 publications

(27 citation statements)

References 39 publications

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“…Terpenoids from seeds of sucupira, especially vouacapan diterpenes, develop a main role as bioactive compounds of this plant [30, 31], being major constituents of the ambar coloured oleoresin obtained from its seeds. This oily material was subjected to some studies aiming to develop emulsions with submicrometer droplets [29, 32].…”

Section: Introductionmentioning

confidence: 99%

Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

et al. 2017

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BackgroundPreparation of nanoformulations using natural products as bioactive substances is considered very promising for innovative larvicidal agents. On this context, oil in water nanoemulsions develop a main role, since they satisfactorily disperse poor-water soluble substances, such as herbal oils, in aqueous media. Pterodon emarginatus, popularly known as sucupira, has a promising bioactive oleoresin. However, to our knowledge, no previous studies were carried out to evaluate its potential against Culex quinquefasciatus, the main vector of the tropical neglected disease called lymphatic filariasis or elephantiasis. Thus, we aimed to investigate influence of different pairs of surfactants in nanoemulsion formation and investigate if a sucupira oleoresin-based nanoemulsion has promising larvicidal activity against this C. quinquefasciatus. We also evaluated morphological alteration, possible mechanism of insecticidal action and ecotoxicity of the nanoemulsion against a non-target organism.ResultsAmong the different pairs of surfactants that were tested, nanoemulsions obtained with polysorbate 80/sorbitan monooleate and polysorbate 80/sorbitan trioleate presented smallest mean droplet size just afterwards preparation, respectively 151.0 ± 2.252 and 160.7 ± 1.493 nm. They presented high negative zeta potential values, low polydispersity index (<0.300) and did not present great alteration in mean droplet size and polydispersity index after 1 day of preparation. Overall, nanoemulsion prepared with polysorbate 80/sorbitan monooleate was considered more stable and was chosen for biological assays. It presented low LC50 value against larvae (34.75; 7.31–51.86 mg/L) after 48 h of treatment and some morphological alteration was observed. The nanoemulsion did not inhibit acetylcholinesterase of C. quinquefasciatus larvae. It was not toxic to green algae Chlorella vulgaris at low concentration (25 mg/L).ConclusionsOur results suggest that optimal nanoemulsions may be prepared with different surfactants using a low cost and low energy simple method. Moreover, this prototype proved to be effective against C. quinquefasciatus, being considered an ecofriendly novel nanoproduct that can be useful in integrated control programs of vector control.

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Section: Introductionmentioning

confidence: 99%

Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

et al. 2017

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“…Pterodon pubescens Benth (Leguminosae), commonly known as “faveira,” “sucupira,” or “sucupira branca,” is a tree native to Brazil and is distributed across its central region [1]. The P. pubescens fruit is traditionally used in ethnomedicine as an infusion [2], in small doses and at regular time intervals as an anti-inflammatory, analgesic, tonic, depurative [3, 4], and hypoglycemic agent [5].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of the Hexane Fraction of the Ethanolic Extract of the Fruits ofPterodon pubescensBenth in Acute and Chronic Inflammation

Hoscheid

Bersani-Amado

Rocha

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Fruits of Pterodon pubescens Benth have been used traditionally for the treatment of rheumatism, sore throat, and respiratory disorders, and also as anti-inflammatory, analgesic, depurative, tonic, and hypoglycemic agent. The study was aimed at evaluating the anti-inflammatory activity of the hexane fraction of an ethanolic extract of P. pubescens fruits. The oil from P. pubescens fruits was extracted with ethanol and partitioned with hexane. The anti-inflammatory activity was measured with increasing doses of the hexane fraction (FHPp) by using a carrageenan-induced rat model of pleurisy and a rat model of complete Freund's adjuvant-induced arthritis by using an FHPp dose of 250 mg/kg for 21 days. Treatment with an FHPp resulted in anti-inflammatory activity in both models. The results of biochemical, hematological, and histological analyses indicated a significant decrease in glucose, cholesterol, and triglycerides levels (18.32%, 34.20%, and 41.70%, resp.) and reduction in the numbers of total leukocytes and mononuclear cells. The FHPp dose of 1000 mg/kg induced no changes in behavioral parameters, and no animal died. The results of this study extend the findings of previous reports that have shown that administration of extracts and fractions obtained from species of the genus Pterodon exhibits anti-inflammatory activity and lacks toxicity.

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“…These species are found in the Brazilian Cerrado and their fruits have often been used in popular medicine for their anti-rheumatic, analgesic and anti-inflammatory properties. 2 Vouacapan furanoditerpenes are constituents of these fruits, and present some pharmacological properties, such as antiinflammatory, 3 antiproliferative against human cancer cells, 4 antiedematogenic 5 and antinociceptive activities. 6 In the present study, two new furanoditerpenes, as well as one that has been previously described in the literature, were obtained from P. emarginatus through semi-preparative high performance liquid chromatography (HPLC).…”

Section: Introductionmentioning

confidence: 99%

Isolation and Structural Characterization of Two New Furanoditerpenes from Pterodon emarginatus (Fabaceae)

Oliveira¹,

Oliveira²,

Lemes³

et al. 2017

J. Braz. Chem. Soc.

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A furanoditerpene-enriched fraction was obtained from the fruits of Pterodon emarginatus and submitted to semipreparative high performance liquid chromatography (HPLC). Two new furanoditerpenes, 6α,19β-diacetoxy-7β,14β-dihydroxyvouacapan and 6α-acetoxy-7β,14β-dihydroxyvouacapan, in addition to the known compound methyl 6α-acetoxy-7β-hydroxyvouacapan-17β-oate were obtained. Compound structures were determined by 1D and 2D nuclear magnetic resonance (NMR) experiments and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS). The major compound methyl 6α-acetoxy-7β-hydroxyvouacapan-17β-oate was evaluated against promastigote forms of Leishmania amazonensis and L. braziliensis, presenting the concentration which causes lysis on 50% of parasites IC 50 < 30 µg mL -1 .

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Pharmaceutical properties of 'sucupira' (Pterodon spp.)

Cited by 35 publications

References 39 publications

Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

Inhibitory Effect of the Hexane Fraction of the Ethanolic Extract of the Fruits ofPterodon pubescensBenth in Acute and Chronic Inflammation

Isolation and Structural Characterization of Two New Furanoditerpenes from Pterodon emarginatus (Fabaceae)

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