Pharmaceutical Sciences—1963. Part I.

Synthesis and antimicrobial activities of sulfonohydrazide‐substituted 8‐hydroxyquinoline derivative and its oxinates

“…The absorption bands of the diffuse electronic spectra and values of their magnetic moments show an octahedral geometry around Ni(II) and Co(II) ions. [37,38] The spectra of [Mn(AHQMBSH) 2 2 ] was not well resolved, it was not well interpreted, but its magnetic moment value shows that it is diamagnetic in nature, as expected. [28] The results of the magnetic moment value (Table 1) were shown to have octahedral geometry for all the M(II) oxinates.…”

“…The use of inorganic base catalyst was avoided, such as sodium/potassium bicarbonate, sodium/potassium hydrogen carbonate and sodium hydroxide, as it either leads to a slow reaction or may give 5-hydroxymethyl-8-hydroxyquinoline in quantitative yield. [4] To overcome these difficulties, triethylamine (TEA) was used as scavenger while reacting CMHQ with 2 had characteristic color, are stable in air and practically insoluble in water, ethanol, methanol, chloroform and hexane, while low solubility was observed in DMF as well as in DMSO.…”

“…[45] The signal due to H 2 of Zn(II) complex appeared at very low magnetic field compared with that of ligand, suggesting the involvement of N 1 in the formation of complex. The protons of N (1) and N (2) in AHQMBSH and its Zn(II) complex resonated as a singlet at δ 10.74, δ 12.48 and δ 10.71, δ 12.47 ppm respectively. This suggested that neither of the nitrogen atoms participated in the complex formation as the chemical shifts remained almost unchanged both in ligand as well as in complex.…”

“…The absorption bands of the diffuse electronic spectra and the value of their magnetic moment favor a tetragonally distorted octahedral geometry around Cu(II) ion. [35,36] [Ni(AHQMBSH) 2 9830, 15490 and 22115 cm −1 , respectively, due to 4 T 1g (F) → 4 T 2g (F), 4 T 1g (F) → 4 A 2g (F) and 4 T 1g (F) → 4 T 1g (P) transitions. The absorption bands of the diffuse electronic spectra and values of their magnetic moments show an octahedral geometry around Ni(II) and Co(II) ions.…”

“…Among the class of hydroxyquinolines, the chemistry of 8-hydroxyquinolines (8HQs) has attracted special interest due to their diverse biological properties [1,2] such as antiamebic, [3] antiseptic and disinfectant, [4,5] antimalarial, [6] antituberculotic, [7] antidiuretic, [8] anticancer, [9,10] antibacterial and antifungal. [11 -13] 8HQ shows remarkable effects similar to the antibiotic, lomofugin, which rapidly and selectively inhibits the RNA synthesis in yeast.…”