Pharmaceutical Sciences—1967

Apparent Directional Permeability Coefficients for Drug Ions: In Vitro Intestinal Perfusion Studies

“…The factors affecting absorption were found to be a function of the diet (high-fat meal) (1, 2), the dosage formulation [particle size (3)(4)(5)(6)(7), dissolution rate (8, 9), solubility (7, lo), and presence of surfactants (4,7)], and the dosage regimen [dosage level (3,11,12) and repetitive dosage schedule (6,7,9, 1 l)].…”

“…Physiological availability-griseofulvin, man Griseofulvin absorption parameters-urinary excretion data, man 0 6-Demethylgriseofulvin metabolite-griseofulvin absorption parameters, man 0 Trimethylsilyl ether derivative-6-demethylgriseofulvin, griseofulvin metabolite 0 GLC-analysis The factors (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) affecting the absorption of orally administered griseofulvin in man have been studied by measuring (using a fluorometric chemical analytical procedure) the level of griseofulvin in blood at various times after drug administration. The calculation of the degree of absorption is based on the assumption that the physiological availability of the drug is proportional to the area (usually determined by the trapezoidal rule) under the blood level-time curve (3,5,(13)(14)(15).…”

Pharmaceutical Sciences-1969: Literature Review of Pharmaceutics

“…It is the eighth annual survey of the series (1)(2)(3)(4)(5)(6)(7). To compile it, numerous periodicals and selected sections of Chemical Abstracts were abstracted.…”

“…0 Biopharmaceutics-1969 literature review This review of the literature represents a comprehensive cross section of the research and development efforts in various selected disciplines of the pharmaceutical sciences. It is the eighth annual survey of the series (1)(2)(3)(4)(5)(6)(7). To compile it, numerous periodicals and selected sections of Chemical Abstracts were abstracted.…”