Pharmaceutical Standardization of “Parada Marita and Vanaspati Jarita Marita Yashada Bhasma” – A Comparative Study

Chandran, Seetha

doi:10.20959/wjpr20178-9195

Cited by 2 publications

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“…Bhasma Pariksha done at different stages of Puta (incineration setup) revealed that PMY fulfilled classical parameters of Bhasma after 7 th Puta, whereas JMY required 5 Puta for the same. [3] Ash value analysis showed that both samples have good solubility in HCl. Variations in the solid content and pH value of the media after Shodhana of Yashada depicts the transfer of certain impurities from the metal to the Shodhana media.…”

Section: Discussionmentioning

confidence: 97%

“…Parada Marita Yashada Bhasma (PMY) and Vanaspati Jarita Marita Yashada Bhasma (JMY) were prepared as per classical Ayurveda guidelines. [3] PMY sample was prepared by means of Pishti preparation with Parada (Mercury) and Gandhaka (sulfur) and JMY sample prepared with prior Jarana (roasting) with Apamarga Panchanga (whole plant of Achyranthes aspera Linn.). [4] Both were subjected to (puta) incineration in electric muffle furnace (EMF).…”

Section: Methods Of Preparation Of Test Drugsmentioning

confidence: 99%

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Chandran¹

2017

IJGP

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Background: Analytical standardization may help to assure adoption of recommended pharmaceutical process, safety, quality, and ultimately, most probably efficacy of medicinal formulation, and thus, it is mandatory for the evaluation of incinerated metallic-mineral preparations, like Yashada Bhasma (incinerated Zinc), a widely used medicine in Ayurvedic therapeutics. The present attempt is to revalidate the pharmaceutical process of preparation of Yashada Bhasma using two different media. Materials and Methods: In this study, analytical standardization of two types of Yashada Bhasma, Vanaspati Jarita Marita Yashada Bhasma (JMY) and Parada Marita Yashada Bhasma (PMY), were initially carried out by means of Bhasma Pariksha (classical methods for evaluating Bhasma). Afterward, this was evaluated by qualitative and quantitative analytical methods such as ash value, dynamic light scattering (DLS), zeta potential, X-ray diffraction (XRD), scanning electron microscopy (SEM), inductively coupled plasma-atomic emission spectrometry (ICPAES), carbon, hydrogen, nitrogen, and sulfur (CHNS), thin layer chromatography (TLC) and Fourier-transform infrared spectroscopy (FTIR). Observation and Discussion: C lassical analytical test revealed that Bhasma prepared fulfilled all criteria. Modern analytical techniques like XRD identified the PMY and JMY as ZnO and ZnS, respectively. Both JMY and PMY samples were in nanorange as per DLS study. As per SEM study, JMY and PMY sample shows 70. 21% and 44.80% of Zn by weight. In inductively coupled plasma-atomic emission spectrometer analysis, micronutrients such as Cu, Fe, Mg, P, Al, Pb, and Zn were present in ≤1% and Ti, Co, Mn, Ni, Cr, and Cd were detected in ppm level in both JMY and PMY samples. Conclusion: Parada Marita Yashada Bhasma was detected as ZnS and Vansapti Jarita Marita Yashada Bhasma as ZnO. As they correspond to different compounds, it cannot be compared analytically and further clinical evaluation is necessary for the same.

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Section: Discussionmentioning

confidence: 97%

Section: Methods Of Preparation Of Test Drugsmentioning

confidence: 99%

Untitled

Chandran¹

2017

IJGP

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“…[10] After this procedure, both samples were subjected to incineration in electric muffle furnace to prepare Bhasma . [11]…”

Section: Methodsmentioning

confidence: 99%

Anticancer activity of Yashada Bhasma (bioactive nanoparticles of zinc): A human pancreatic cancer cell line study

Chandran

Patgiri

Bedarkar

et al. 2019

AYU

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Background:Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer-related mortality. Efforts to improve cancer treatment through nanotechnology are at the developmental stage, and it will be gracious if the drug with anticancer property itself is a nanoparticle. Bhasma is organomineral complexes which are bioactive nanoparticles. Yashada Bhasma (incinerated processed zinc) is widely used in Ayurveda for various diseases, and there are evidence that ZnO nanoparticles are promising antitumor agent. However, no studies have been conducted on the effectiveness of Yashada Bhasma in pancreatic cancer.Materials and Methods:Two types of test drugs, Parada Marita Yashada Bhasma (PMY) and Vanaspati Jarita Marita Yashada Bhasma (JMY), were prepared as per the guidelines of pharmaceutics of Ayurveda. Particle size analyses of Yashada Bhasma and Zeta potential study was carried out initially. Further human pancreatic cancer cell line (MIA PaCa-2) study was done using in vitro sulforhodamine B assay, keeping adriamycinas control. After 48 h of incubation, antiproliferative effects were assessed.Results:JMY and adriamycin showed dose-dependent growth inhibition of cancer cells. Both Yashada Bhasma samples showed a cytostatic effect at this concentration.Conclusion:The study leads to new avenues for cancer treatment by developing such unique and highly effective bioactive nano-sized therapeutic agent.

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Pharmaceutical Standardization of “Parada Marita and Vanaspati Jarita Marita Yashada Bhasma” – A Comparative Study

Abstract: Introduction: Yashada bhasma (Calx of Zinc) is a metallic

Cited by 2 publications

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Anticancer activity of Yashada Bhasma (bioactive nanoparticles of zinc): A human pancreatic cancer cell line study

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