Pharmaceuticals and endocrine disruptors in raw and cooked seafood from European market: Concentrations and human exposure levels

Álvarez-Muñoz, Diana; Rodríguez-Mozaz, Sara; Jacobs, Silke; Serra-Compte, Albert; Cáceres, Núria; Sioen, Isabelle; Verbeke, Wim; Barbosa, Vera; Ferrari, Federico; Fernández-Tejedor, Margarita; Cunha, Sara C.; Granby, Kit; Robbens, Johan; Kotterman, M.J.J.; Marques, António; Barceló, Damià

doi:10.1016/j.envint.2018.07.006

Cited by 47 publications

(22 citation statements)

References 69 publications

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“…74 We found a strong positive association between education and methyl paraben concentrations that, to our knowledge, has not been reported elsewhere. Since methyl paraben has been detected in seafood 83 and, in the U.S., seafood consumption is higher among adults with greater educational attainment, 84 this finding may reflect dietary patterns that differ by education.…”

Section: Discussionmentioning

confidence: 99%

Correlates of exposure to phenols, parabens, and triclocarban in the Study of Environment, Lifestyle and Fibroids

Bethea

Wesselink

Weuve

et al. 2019

J Expo Sci Environ Epidemiol

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We performed a cross-sectional analysis to identify correlates of urinary concentrations of seven phenols (bisphenols A, F, and S, 2,4-dichlorophenol, 2,5-dichlorophenol, benzophenone-3, triclosan), triclocarban, and four parabens (butyl, ethyl, methyl, and propyl). We analyzed baseline data from 766 participants in the Study of Environment, Lifestyle, and Fibroids, a prospective cohort study of 1 693 Black women aged 23–34 years residing in Detroit, Michigan (2010–2012). We collected data on demographic, behavioral, and anthropometric factors via telephone interviews, clinic visits, and self-administered questionnaires. For each biomarker, we used linear regression models to estimate mean differences in log-transformed, creatinine-corrected concentrations across factors of interest. Each biomarker was detected in >50% of participants. Median creatinine-corrected concentrations were highest for methyl paraben (116.8 μg/g creatinine), propyl paraben (16.8 μg/g creatinine), and benzophenone-3 (13.4 μg/g creatinine). Variables most strongly associated with biomarker concentrations included season of urine collection, education, and body mass index (BMI). BMI was positively associated with bisphenol A and S and triclocarban concentrations and inversely associated with butyl and methyl paraben concentrations. In this cohort of Black women, exposure to phenols, parabens, and triclocarban was prevalent and several factors were associated with biomarker concentrations.

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Section: Discussionmentioning

confidence: 99%

Correlates of exposure to phenols, parabens, and triclocarban in the Study of Environment, Lifestyle and Fibroids

Bethea

Wesselink

Weuve

et al. 2019

J Expo Sci Environ Epidemiol

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“…Triclosan (TCS) and triclocarban (TCC) (TCs) are chlorinated, broad-spectrum antimicrobial endocrine disrupting chemicals found in thousands of consumer and industrial products [141], as well as in contaminated food [142,143]. These EDCs have been related to metabolic disorders such as obesity and diabetes [144,145].…”

Section: Triclosan and Triclocarbanmentioning

confidence: 99%

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

et al. 2020

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Endocrine disruptors (EDCs) have been associated with the increased incidence of metabolic disorders. In this work, we conducted a systematic review of the literature in order to identify the current knowledge of the interactions between EDCs in food, the gut microbiota, and metabolic disorders in order to shed light on this complex triad. Exposure to EDCs induces a series of changes including microbial dysbiosis and the induction of xenobiotic pathways and associated genes, enzymes, and metabolites involved in EDC metabolism. The products and by-products released following the microbial metabolism of EDCs can be taken up by the host; therefore, changes in the composition of the microbiota and in the production of microbial metabolites could have a major impact on host metabolism and the development of diseases. The remediation of EDC-induced changes in the gut microbiota might represent an alternative course for the treatment and prevention of metabolic diseases.

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“…Food packaging represents the major source of human exposure to bisphenols. A list of foods containing bisphenols and relative concentrations is provided in Table 1 (6)(7)(8)(9). The hydrolysis of the ester bonds that link bisphenol monomers is accelerated by heat, as well as acids and bases (2).…”

Section: Sources Of Exposurementioning

confidence: 99%

“…For children, median BPA level are also higher (1.25 µg/L) than BPF and BPS (0.32 and 0.29 µg/L, respectively). Bisphenol S is found in 81% of samples representing the US and seven Asian countries (3,9). In the 2013-2014 NHANES database, BPA is found at higher concentrations among low socioeconomic status individuals and in children.…”

Section: Human Environmental Exposuresmentioning

confidence: 99%

Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components

et al. 2020

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Data from preclinical studies suggest a link between increased risk of breast cancer and exposure to bisphenols at doses below what the United States Food and Drug Administration (FDA) considers as safe for consumption. Bisphenols exert estrogenic effects and are found in canned and plastic wrapped foods, food packaging, and plasticware. Mechanistically, bisphenols bind to the estrogen receptor (ER) and activate the expression of genes associated with cell proliferation and breast cancer. In this paper, we present a narrative literature review addressing bisphenol A and chemical analogs including bisphenol AF, bisphenol F, and bisphenol S selected as prototype xenoestrogens; then, we discuss biological mechanisms of action of these bisphenols in breast cells and potential impact of exposure at different stages of development (i.e., perinatal, peripubertal, and adult). Finally, we summarize studies detailing interactions, both preventative and promoting, of bisphenols with food components on breast cancer risk. We conclude the review with a discussion of current controversies in interpretation of the above research and future areas for investigation, including the impact of bisphenols and food components on breast tumor risk.

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Pharmaceuticals and endocrine disruptors in raw and cooked seafood from European market: Concentrations and human exposure levels

Cited by 47 publications

References 69 publications

Correlates of exposure to phenols, parabens, and triclocarban in the Study of Environment, Lifestyle and Fibroids

Correlates of exposure to phenols, parabens, and triclocarban in the Study of Environment, Lifestyle and Fibroids

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components

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