Pharmaceuticals in groundwaters

Sacher, Frank; Lange, Frank Thomas; Brauch, Heinz‐Jürgen; Blankenhorn, Iris

doi:10.1016/s0021-9673(01)01266-3

Cited by 740 publications

(165 citation statements)

References 8 publications

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“…It was shown that the recoveries for sulfapyridine and sulfamethazine in all the samples were rather satisfactory and in the range of 85-102%, but the recoveries of sulfathiazole and sulfadiazine were relatively lower in all samples, and the spiked recoveries for sulfathiazole and sulfadiazine were in the range of 55-79% and 72-92%, respectively. Compared with the recov- eries of sulfonamides obtained in other studies, the extraction efficiency of MWCNTs adsorbent was superior to MCX adsorbents (mixed mode strong cation exchange resin) (recoveries of sulfadiazine and sulfathiazole were less than 50%) [48] or C 2 /EVN + adsorbents (recoveries of sulfadiazine and sulfathiazole were no more than 20%) [50,56]. Furthermore, with the exception of sulfathiazole, the recoveries of sulfonamides were comparable with those extracted by hydrophilic-lipophilic balance (HLB) copolymer wildly used adsorbent for antibiotics [51][52][53][54][55][56].…”

Section: Analytical Performance and Sample Analysesmentioning

confidence: 63%

“…Compared with the recov- eries of sulfonamides obtained in other studies, the extraction efficiency of MWCNTs adsorbent was superior to MCX adsorbents (mixed mode strong cation exchange resin) (recoveries of sulfadiazine and sulfathiazole were less than 50%) [48] or C 2 /EVN + adsorbents (recoveries of sulfadiazine and sulfathiazole were no more than 20%) [50,56]. Furthermore, with the exception of sulfathiazole, the recoveries of sulfonamides were comparable with those extracted by hydrophilic-lipophilic balance (HLB) copolymer wildly used adsorbent for antibiotics [51][52][53][54][55][56]. As sulfamethazine was one of the most commonly used sulfonamides mainly for veterinary applications [51], it could be frequently detected in environmental aqueous samples.…”

Section: Analytical Performance and Sample Analysesmentioning

confidence: 63%

“…It has been reported that sulfonamides have high potential to resist degradation, and can be transferred into aquatic environment [46]. Several of sulfonamides (such as sulfamethazine and sulfamethoxazole) have been detected in wastewater, surface water, and even groundwater samples [47][48][49][50][51][52][53][54][55][56], which has led to great concerns about the potential for the development of antimicrobial resistance amongst microorganisms. Consequently sulfonamides were used as model compounds in this section.…”

Section: Analytical Performance and Sample Analysesmentioning

confidence: 99%

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Evaluation of carbon nanotubes as a solid-phase extraction adsorbent for the extraction of cephalosporins antibiotics, sulfonamides and phenolic compounds from aqueous solution

Niu

Cai

Shi

et al. 2007

Analytica Chimica Acta

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The adsorptive potential of carbon nanotubes (single-walled carbon nanotubes and multi-walled carbon nanotubes) for solid-phase extraction of three groups of highly polar compounds (namely cephalosporins antibiotics, sulfonamides and phenolic compounds) was tested in this article. The analytes were strongly retained by the carbon nanotubes. And acceptable recoveries were obtained with the addition of ammonium acetate into eluents. The effects of solution pH on the recoveries of the antibiotics and phenolic compounds were examined. To check the retention abilities of three groups of compounds on carbon nanotubes, fixed amount of each analyte was added to different volumes (up to 500 mL) of aqueous solution, and then extracted by the sorbents. Comparative studies showed that the carbon nanotubes were much superior to C 18 for the extraction of the highly polar analytes. For the cephalosporins antibiotics and sulfonamides, the carbon nanotubes showed stronger retention capability than graphitized carbon blacks, but for some of the phenolic compounds graphitized carbon blacks seemed to be more suitable, indicating different retention mechanisms of these analytes. To further assess the enrichment ability of carbon nanotubes for highly polar compounds, the solid-phase extraction method of multi-walled carbon nanotubes packed cartridge was well developed, and the sulfonamides were used as model compounds. Under the optimal procedures, the detection limits of sulfonamides were in the range of 27-38 ng L −1 . The spiked recoveries from several real water samples obtained for sulfathiazole and sulfadiazine ranged from 55% to 79% and 72% to 92%, respectively, while the recoveries of sulfapyridine and sulfamethazine were in the range of 85-102%.

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Section: Analytical Performance and Sample Analysesmentioning

confidence: 63%

Section: Analytical Performance and Sample Analysesmentioning

confidence: 63%

Section: Analytical Performance and Sample Analysesmentioning

confidence: 99%

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Evaluation of carbon nanotubes as a solid-phase extraction adsorbent for the extraction of cephalosporins antibiotics, sulfonamides and phenolic compounds from aqueous solution

Niu

Cai

Shi

et al. 2007

Analytica Chimica Acta

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Section: Introductionmentioning

confidence: 99%

“…9 Studies have found residues of pharmaceuticals and their metabolites, from ng L -1 to mg L -1 levels, in aquatic environments in countries including Germany, Brazil, Canada, Holland, UK, Italy, Sweden and the USA. [10][11][12][13] However, since these chemicals belong to an emerging class of pollutants, the literature is still sparse concerning their behavior and interactions in hydric systems.Aquatic humic substances (AHS), the most important class of complexation agents present in the natural environment, play an important role in the transport and behavior of ED. 14 Characterization of the interactions of ED with AHS, exploring the formation and stability of possible ED-AHS complexes, can therefore provide important information concerning the availability of ED to aquatic biota.…”

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confidence: 99%

Characterization of the interactions between endocrine disruptors and aquatic humic substances from tropical rivers

Botero¹,

Oliveira²,

Cunha³

et al. 2011

J. Braz. Chem. Soc.

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Interações entre substâncias húmicas aquáticas (SHA), de rios tropicais, e dois interferentes endócrinos (IE) foram estudados utilizando sistema de ultrafiltração em fluxo tangencial equipado com membrana de celulose de 1 kDa com a finalidade de separar os IE livres da fração ligada as SHA. A quantificação de 17a-etinilestradiol e bisfenol A foi realizada utilizando cromatógrafo a gás acoplado a espectrômetro de massas (GC-MS). O tempo de equilíbrio entre as SHA e IE foi de aproximadamente 30 min, e as capacidades complexantes do 17a-etinilestradiol e bisfenol A foram em torno de 18,53 e 2,07 mg g -1 de carbono orgânico total (COT), respectivamente. A maior interação das SHA ocorreu para 17a-etinilestradiol, em relação ao bisfenol A, devido a presença de hidrogênio na estrutura do 17a-etinilestradiol, que podem interagir com os grupos oxigenados presentes nas SHA. Os resultados indicam que as SHA podem influenciar fortemente no transporte e reatividade dos interferentes endócrinos presentes em sistemas aquáticos.Interactions between two endocrine disruptors (ED) and aquatic humic substances (AHS) from tropical rivers were studied using an ultrafiltration system equipped with a 1 kDa cut-off cellulose membrane to separate free ED from the fraction bound in the AHS. Quantification of 17a-ethynylestradiol and bisphenol A was performed using gas chromatography-mass spectrometry (GC-MS). The times required for establishment of equilibrium between the AHS and the ED were ca. 30 min, and complexation capacities for 17a-ethynylestradiol and bisphenol A were 18.53 and 2.07 mg g -1 TOC, respectively. The greater interaction of AHS with 17a-ethynylestradiol, compared to bisphenol A, was due to the presence of hydrogen in the structure of 17a-ethynylestradiol, which could interact with ionized oxygenated groups of the AHS. The results indicate that AHS can strongly influence the transport and reactivity of endocrine disruptors in aquatic systems.Keywords: water, pollution, endocrine disruptors, aquatic humic substances, complexation capacity IntroductionPopulation increase, the development of new products, and intensified use of terrestrial and aquatic resources in industry and agriculture have resulted in the introduction into the environment of new compounds that may cause toxicity in humans and animals. Endocrine disruptors (ED) are often found in surface waters and effluents, where they can pose health risks even at low concentrations. In 1996, the European Commission defined this class of compounds as "exogenous substances that cause adverse health effects in the intact organism, or in its descendents, resulting in alterations of endocrine functions". 1,2 ED can block cellular receptor sites or increase the production and/or secretion of hormones, hence interfering in the reproductive systems of living organisms. 3-5 Many Characterization of the Interactions between Endocrine Disruptors and Aquatic Humic Substances J. Braz. Chem. Soc. 1104 compounds are suspected of interfering with the endocrine system, 6 inclu...

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Analytical Methods for Polar Pollutants

Reemtsma

Quintana

2006

Organic Pollutants in the Water Cycle

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Pharmaceuticals in groundwaters

Cited by 740 publications

References 8 publications

Evaluation of carbon nanotubes as a solid-phase extraction adsorbent for the extraction of cephalosporins antibiotics, sulfonamides and phenolic compounds from aqueous solution

Evaluation of carbon nanotubes as a solid-phase extraction adsorbent for the extraction of cephalosporins antibiotics, sulfonamides and phenolic compounds from aqueous solution

Characterization of the interactions between endocrine disruptors and aquatic humic substances from tropical rivers

Analytical Methods for Polar Pollutants

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