Pharmaceuticals in the river Elbe and its tributaries

Wiegel, S.; Aulinger, Armin; Brockmeyer, Robert; Harms, Heinz; Löffler, Joachim; Reincke, Heinrich; Schmidt, R.; Stachel, Burkhard; Tümpling, Wolf von; Wanke, A.

doi:10.1016/j.chemosphere.2004.05.017

Cited by 367 publications

(139 citation statements)

References 20 publications

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“…Although the frequencies of CTM, AZM, RTM and STZ were all greater than 20%, their concentrations were lower than 1 ng L À1 , which may reflect rather low consumption in this region. Obviously, the concentrations of most of the antibiotics studied are much lower than those found in the Haihe River and its tributaries in China , and similar to those observed in the Elbe River, Germany (Wiegel et al, 2004) and the Tyne River, United Kingdom (Roberts and Thomas, 2006).…”

Section: Occurrence Of the Selected Antibiotics In Riverssupporting

confidence: 61%

“…Perhaps because TMP is used as a synergist of sulfonamides, not only in combination with SMX in human medicine but also with SDZ in aquaculture (Graslund and Bengtsson, 2001), it showed the third highest detection frequency of 88.6%, with concentrations up to 3.77 ng L À1 . It could be seen from Table 1 that the concentrations of the above three antibiotics are comparable to those measured in the Elbe River, Germany (Wiegel et al, 2004), Tyne River, United Kingdom (Roberts and Thomas, 2006) and the Mekong Delta, Vietnam (Managaki et al, 2007), but are much lower than those found in the Pearl River, South China, even in the low-water season (Xu et al, 2007b) and in 139 streams studied in America (Kolpin et al, 2002).…”

Section: Occurrence Of the Selected Antibiotics In The Beibu Gulfmentioning

confidence: 54%

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Occurrence and distribution of antibiotics in the Beibu Gulf, China: Impacts of river discharge and aquaculture activities

Zheng

Zhang

Wang

et al. 2012

Marine Environmental Research

209

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Section: Occurrence Of the Selected Antibiotics In Riverssupporting

confidence: 61%

Section: Occurrence Of the Selected Antibiotics In The Beibu Gulfmentioning

confidence: 54%

Occurrence and distribution of antibiotics in the Beibu Gulf, China: Impacts of river discharge and aquaculture activities

Zheng

Zhang

Wang

et al. 2012

Marine Environmental Research

209

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“…It has been found with a concentration of up to 6 μgL −1 in European sewage effluents (Ternes 1998), up to 10 μgL −1 in US natural waters (Kolpin et al 2002), and more than 65 μgL −1 in Tyne River in the UK (Robert and Thomas 2006 Kolpin et al (2002) detected acetaminophen in roughly 25 % of the samples tested at a median concentration of 0.11 μgL −1 . The median concentration of paracetamol detected in surface waters is 0.055±0.051 μgL −1 (Wiegel et al 2004;Bound and Voulvoulis 2006;Gros et al 2006). In raw wastewater, paracetamol was detected at a median concentration of 48±75 μgL −1 (Han et al 2006;Gomez et al 2007).…”

Section: Paracetamol In the Environmentmentioning

confidence: 95%

“…In addition, in-depth characterization of genes and enzyme systems involved in the utilization of paracetamol has led to an improved understanding of microbial paracetamol metabolism. A large number of (Kolpin et al 2002) (Gros et al 2006) 0.007-0.066 (Wiegel et al 2004) 6 (Ternes 1998) 0.048-0.418 (Radjenovic et al 2007) 10 ( Kolpin et al 2002) 0.079-0.22 (Bound and Voulvoulis 2006) microorganisms belonging to the phyla of eubacteria, yeast, and fungi and also some algae capable of using paracetamol as carbon and energy source have been described. A listing of isolated bacterial strains characterized for the degradation of those paracetamols is presented in Table 2.…”

Section: Biodegradation Of Paracetamol By Pure Culturementioning

confidence: 99%

Paracetamol in the environment and its degradation by microorganisms

Zhang

Chen

2012

Appl Microbiol Biotechnol

245

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Paracetamol (4′-hydroxyacetanilide, N-acetyl-paminophenol, acetaminophen, and paracetamol) is a widely used over-the-counter analgesic and antipyretic drug. Paracetamol and structural analogs are ubiquitous in the natural environment and easily accumulate in aquatic environment, which have been detected in surface waters, wastewater, and drinking water throughout the world. Paracetamol wastewater is mainly treated by chemical oxidation processes. Although these chemical methods may be available for treating these pollutants, the harsh reaction conditions, the generation of secondary pollutants, and the high operational cost associated with these methods have often made them not a desirable choice. Biodegradation of paracetamol is being considered as an environmentally friendly and low-cost option. The goal of this review is to provide an outline of the current knowledge of biodegradation of paracetamol in the occurrence, degrading bacteria, and proposed metabolic/ biodegrading pathways, enzymes and possible intermediates. The comprehensive understanding of the metabolic pathways and enzyme systems involved in the utilization of paracetamol means will be helpful for optimizing and allowing rational design of biodegradation systems for paracetamol-contaminated wastewater.

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“…In these areas, intensive human activities may release antibiotics from pharmaceutical sources. It was observed that in some developed regions, antibiotics used in human medicine were the major sources of antibiotics in the aquatic environment (Wiegel et al 2004). Therefore, the significant positive correlation between TC and developed area indicated that human sources might be a major contributor of TC.…”

Section: Correlation With Land Use Typesmentioning

confidence: 99%

Sources identification of antibiotic pollution combining land use information and multivariate statistics

Zhang

Chen

et al. 2016

Environ Monit Assess

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To quantify the extent of antibiotic contamination and to identity the dominant pollutant sources in the Tiaoxi River Watershed, surface water samples were collected at eight locations and analyzed for four tetracyclines and three sulfonamides using ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The observed maximum concentrations of tetracycline (623 ng L ) exceeded their corresponding Predicted No Effect Concentration (PNEC) values. In particular, high concentrations of antibiotics were observed in wet summer with heavy rainfall. The maximum concentrations of antibiotics appeared in the vicinity of intensive aquaculture areas. High-resolution land use data were used for identifying diffuse source of antibiotic pollution in the watershed. Significant correlations between tetracycline and developed (r = 0.93), tetracycline and barren (r = 0.87), oxytetracycline and barren (r = 0.82), and sulfadiazine and agricultural facilities (r = 0.71) were observed. In addition, the density of aquaculture significantly correlated with doxycycline (r = 0.74) and oxytetracycline (r = 0.76), while the density of livestock significantly correlated with sulfadiazine (r = 0.71). Principle Component Analysis (PCA) indicated that doxycycline, tetracycline, oxytetracycline, and sulfamethoxazole were from aquaculture and domestic sources, whereas sulfadiazine and sulfamethazine were from livestock wastewater. Flood or drainage from aquaculture ponds was identified as a major source of antibiotics in the Tiaoxi watershed. A hot-spot map was created based on results of land use analysis and multivariable statistics, which provided an effective management tool of sources identification in watersheds with multiple diffuse sources of antibiotic pollution.

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Pharmaceuticals in the river Elbe and its tributaries

Cited by 367 publications

References 20 publications

Occurrence and distribution of antibiotics in the Beibu Gulf, China: Impacts of river discharge and aquaculture activities

Occurrence and distribution of antibiotics in the Beibu Gulf, China: Impacts of river discharge and aquaculture activities

Paracetamol in the environment and its degradation by microorganisms

Sources identification of antibiotic pollution combining land use information and multivariate statistics

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