Pharmaceuticals in water, fish and osprey nestlings in Delaware River and Bay

Bean, Thomas G.; Rattner, Barnett A.; Lazarus, Rebecca S.; Day, Daniel D.; Burket, S. Rebekah; Brooks, Bryan W.; Haddad, Samuel P.; Bowerman, William W.

doi:10.1016/j.envpol.2017.09.083

Cited by 89 publications

(44 citation statements)

References 59 publications

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“…Across all sites, the top five most frequently detected pharmaceuticals in riparian spiders were tramadol, codeine, fluconazole, metoprolol and clomipramine (Supplementary Fig 1 ). Our findings complement other research demonstrating that non-aquatic animals may be exposed to drugs originating from aquatic ecosystems 29 , 30 .…”

Section: Resultssupporting

confidence: 89%

A diverse suite of pharmaceuticals contaminates stream and riparian food webs

et al. 2018

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A multitude of biologically active pharmaceuticals contaminate surface waters globally, yet their presence in aquatic food webs remain largely unknown. Here, we show that over 60 pharmaceutical compounds can be detected in aquatic invertebrates and riparian spiders in six streams near Melbourne, Australia. Similar concentrations in aquatic invertebrate larvae and riparian predators suggest direct trophic transfer via emerging adult insects to riparian predators that consume them. As representative vertebrate predators feeding on aquatic invertebrates, platypus and brown trout could consume some drug classes such as antidepressants at as much as one-half of a recommended therapeutic dose for humans based on their estimated prey consumption rates, yet the consequences for fish and wildlife of this chronic exposure are unknown. Overall, this work highlights the potential exposure of aquatic and riparian biota to a diverse array of pharmaceuticals, resulting in exposures to some drugs that are comparable to human dosages.

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Section: Resultssupporting

confidence: 89%

A diverse suite of pharmaceuticals contaminates stream and riparian food webs

et al. 2018

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“…For example, Table 1 presents analytically verified concentrations of each treatment level. This protocol verified water samples for caffeine treatment levels by isotope-dilution liquid chromatography tandem mass spectrometry (LC-MS/MS) generally following previously reported methods 28 . The formation of paraxanthine, the primary metabolite of caffeine, was also quantified.…”

Section: Representative Resultssupporting

confidence: 53%

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine

Steele

Molé

Brooks

2018

JoVE

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Fish models and behaviors are increasingly used in the biomedical sciences; however, fish have long been the subject of ecological, physiological and toxicological studies. Using automated digital tracking platforms, recent efforts in neuropharmacology are leveraging larval fish locomotor behaviors to identify potential therapeutic targets for novel small molecules. Similar to these efforts, research in the environmental sciences and comparative pharmacology and toxicology is examining various behaviors of fish models as diagnostic tools in tiered evaluation of contaminants and real-time monitoring of surface waters for contaminant threats. Whereas the zebrafish is a popular larval fish model in the biomedical sciences, the fathead minnow is a common larval fish model in ecotoxicology. Unfortunately, fathead minnow larvae have received considerably less attention in behavioral studies. Here, we develop and demonstrate a behavioral profile protocol using caffeine as a model neurostimulant. Though photomotor responses of fathead minnows were occasionally affected by caffeine, zebrafish were markedly more sensitive for photomotor and locomotor endpoints, which responded at environmentally relevant levels. Future studies are needed to understand comparative behavioral sensitivity differences among fish with age and time of day, and to determine whether similar behavioral effects would occur in nature and be indicative of adverse outcomes at the individual or population levels of biological organization.

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“…These polluted water bodies are a great threat to aquatic flora and fauna, and human health [5,6]. For example, it is confirmed an increased risk of Active Pharmaceutical Ingredients (APIs) on the exposed wildlife [7]. I was found that the transfer of APIs is through the progressive tropic levels in a water-fish-osprey food chain in Delaware and Bay Rivers.…”

Section: Introductionmentioning

confidence: 98%

Identifying the Key Information and Land Management Plans for Water Conservation under Dry Weather Conditions in the Border Areas of the Syr Darya River in Kazakhstan

Yegemova

Kumar

Abuduwaili

et al. 2018

Water

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Due to an increase in poorly planned anthropogenic activities, the water quality of several Asian big rivers is highly being affected. Although the assessment of heavy metal contents is vital to develop and design sustainable water management plans, several areas in Central Asia such as Kazakhstan do not have recent studies available that evaluate this situation. One representative example of this lack of information is the Syr Darya River. Thus, this study carried out the first approach to a water quality assessment in Kazakhstan’s Syr Darya River, where a massive expansion of irrigation canals, pastures in middle- and lower-reaches and an increase in industrialization and population have lowered its potential water capacity. To achieve this goal, various physicochemical parameters were analyzed for forty-three water samples along the river under dry weather conditions at 25 cm water depth. The obtained results were analyzed using standard methods (e.g., Multi N/C 2100 S analyzer or an atomic absorption spectrometer) and evaluated by multivariate techniques (cluster analysis (CA), principal component analysis (PCA), and non-metric multidimensional scaling (NDMS)) and a heavy metal pollution index (HPI). In the CA, five cluster groups were obtained. It is important to remark that the first cluster consists of the highest number of water sampling points (8). The last cluster is made up of only one point, which shows the highest difference against the other sites in our model. The NDMS also confirmed that some specific points along the river are different. Five components were extracted from the PCA: (1) COD (chemical oxygen demand), Zn, Cu, Pb, Ni and Mn; (2) Cu, Cd, Ni and Co; (3) T (water temperature), pH and DO (dissolved oxygen); (4) T and Fe; and (5) COD and OC (organic carbon). The HPI showed very high values (279.9), which were locally confirmed in some hotspots close to the Aral Sea, industrialized areas and agricultural fields. Therefore, our results demonstrate that, under dry weather conditions, surface water resources could be mismanaged in the Syr Darya River in Kazakhstan in specific areas. For the future, considering the important role that agriculture and pasture play in the Kazakh economy, we insist upon the importance of applying water quality control measures applying nature-based solutions and efficient management plans. Moreover, we confirmed the necessity to conduct further research related to sampling under other weather situations such as wet and cold conditions, different river water depths and other locations considering specific land uses, for example, grazing, mining, railways or industries.

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Pharmaceuticals in water, fish and osprey nestlings in Delaware River and Bay

Cited by 89 publications

References 59 publications

A diverse suite of pharmaceuticals contaminates stream and riparian food webs

A diverse suite of pharmaceuticals contaminates stream and riparian food webs

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine

Identifying the Key Information and Land Management Plans for Water Conservation under Dry Weather Conditions in the Border Areas of the Syr Darya River in Kazakhstan

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