Pharmacist surveillance of adverse drug events

Forster, Alan J.; Halil, Roland; Tierney, Michael

doi:10.1093/ajhp/61.14.1466

Cited by 39 publications

(23 citation statements)

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“…We found that antimicrobials were the group of drugs most involved in PE, followed by nervous system‐related therapy and antineoplastic agents. These results are consistent with those of other studies, which found antimicrobials to be the most frequently involved group of drugs [10,28,30–32]. Specifically, we found that the most common errors were incorrect dose of antimicrobials in renal impairment, incorrect route and excessive length of empirical treatment.…”

Section: Discussionsupporting

confidence: 92%

Adding value through pharmacy validation: a safety and cost perspective

Ibáñez-García

Rodríguez-González

Martin-Barbero

et al. 2015

Evaluation Clinical Practice

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Section: Discussionsupporting

confidence: 92%

Adding value through pharmacy validation: a safety and cost perspective

Ibáñez-García

Rodríguez-González

Martin-Barbero

et al. 2015

Evaluation Clinical Practice

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“…Adverse drug events (ADEs) are the most common safety-concerning events occurring in hospitals [1-3]. ADEs occur in 2.4 to 5.2/100 adult hospitalized patients [4-7], increasing both the length of hospital stays by 2.2 days and hospital costs by $1,900 to $5,900 [4,8].…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Active Surveillance Programs Including a Spontaneous Reporting Model for Phamacovigilance of Adverse Drug Events in a Hospital

Yun

Koo

Park

et al. 2012

Korean J Intern Med

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Background/AimsSpontaneous reporting systems have several weak points, such as low reporting rates and insufficient clinical information. Active surveillance programs, such as ward rounds and a clinical data repository (CDR), may supplement the weak points of such systems. We developed active surveillance programs and compared them with existing spontaneous reporting.MethodsWe collected adverse drug event (ADE) cases, which comprised 1,055 cases of spontaneous reporting, 309 reported by ward rounds, and 229 found using a CDR. The clinical features and causative drugs were evaluated.ResultsActive surveillance programs detected additional serious ADEs compared to those of spontaneous reporting programs. The ADEs identified by CDR (22.9%) were more likely to be classified as "serious" than those reported spontaneously (5.2%) or identified during ward rounds (10.3%). Causative drugs also differed. Opioids, antibiotics, and contrast media were the most common drugs causing ADEs in the spontaneous reporting system, whereas the active surveillance programs identified antibiotics as the most common causative drug. Clinical features also differed. ADEs with gastrointestinal manifestations were reported most frequently by spontaneous reporting programs. ADEs reported from active surveillance more reliably identified events associated with changes in laboratory values, such as hepatobiliary toxicity, hematologic manifestations, and nephrologic manifestations, compared with spontaneous reporting programs.ConclusionsOur findings suggest that active surveillance programs can supplement spontaneous reporting systems in hospitals. ADEs related to laboratory abnormalities were monitored more closely by active surveillance programs and may be useful for identification of serious ADEs.

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“…Respondents generally favoured increased technology use, despite the low methodological quality of studies that suggest they are beneficial; despite likely uncertainty and underestimation of patient harm due to medication error [1–3]; and despite some practical concerns expressed about technology implementation.…”

Section: Discussionmentioning

confidence: 99%

“…A Canadian population‐based study identified adverse drug events (ADEs) in 1.8% of adult, non‐obstetric, non‐psychiatric hospital admissions [1]; in the USA, half of such events were deemed preventable [2]. More sensitive methods of ADE identification suggested an even greater risk of preventable ADEs [3]. Even the Romanow Report declared that ‘the health care system itself is a major cause of illness, death and added costs because of errors, infections, [and] the adverse effects of medications’[4].…”

Section: Introductionmentioning

confidence: 99%