Pharmaco-technical profile of Lythri herba freeze-dried extract based on SeDeM methodology

Iancu, Valeriu; Iancu, Irina Mihaela; Roncea, Fiorentina Nicoleta; Mireșan, Horațiu; Cazacincu, Radu; Schröder, Verginica; Blebea, Nicoleta Mirela; Mitea, Gabriela

doi:10.1109/ehb52898.2021.9657552

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…The results obtained are encouraging and suggest that adjusting the concentrations of the two components in the mixture may serve as a modulating factor for the effects of bacterial anti-adhesiveness and biocompatibility, as well as correlation with the studies about standardization of the extract [99]. Nevertheless, the subsequent studies endeavor to consolidate the information pertaining to prolonging the duration of exposure beyond 24 h while also diversifying the control experiments.…”

Section: Discussionmentioning

confidence: 82%

Biocompatibility of Membranes Based on a Mixture of Chitosan and Lythri herba Aqueous Extract

Iancu,

Schröder,

Apetroaei

et al. 2023

Applied Sciences

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In the current context of concern for the improvement and protection of environmental conditions, emphasis is placed on the provision of non-toxic, eco-friendly, renewable biomaterials to replace established chemical substances. Lythri herba is the aerial part of the plant species Lythrum salicaria L., known in the scientific literature especially for its content of tannins and total polyphenols, which highlight its antioxidant, hemostatic, antibacterial and antidiarrheal properties. Chitosan is a biopolymer widely used in industry and medicine due to its abundance in nature, its biodegradability, lack of toxicity and the ease with which it can be transformed into several basic forms (hydrogel, membrane, sponge). The aqueous solutions and membranes obtained in this study by merging these two natural resources were biologically tested in terms of genotoxicity (SOS-Chromo assay), hemolytic activity, thrombin generation activity and bacterial adhesion to reveal outwardly the lack of these properties and their use for medical purposes. The results of the current study attest to the absence of mutagenic and slight hemolyzing properties, thus supporting the possibility of using this extract and membrane in medical and pharmaceutical therapeutic practice. The surface parameters of membranes were examined and important influences at thrombin activity were found. Also, bacterial adhesion results showed a correlation between Lythri herba and chitosan concentrations and membranes’ appearances (swelling, stability). The results show that the membranes could be a promising material for biomedical applications.

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Section: Discussionmentioning

confidence: 82%