Pharmacodynamic analysis of the furosemide-probenecid interaction in man

Chennavasin, Polavat; Seiwell, Ruth; Brater, D. Craig; Liang, Winnie M.M.

doi:10.1038/ki.1979.120

Cited by 140 publications

(87 citation statements)

References 24 publications

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“…The effect is at best minor, although in the present study indomethacin caused both a significant decrease in the amount of sodium excreted in the first hour, and a small inhibition of urine flow in the first 40 min after frusemide. Although controversial (Chennovasin et al, 1980), it seems unlikely that indomethacin interferes with the renal excretion of frusemide (Data et al, 1978). However only a very small change in delivery of the drug to the ascending limb of Henle could probably explain the observed effects on sodium excretion.…”

Section: Prostaglandins and Frusemide 517mentioning

confidence: 99%

Contribution of prostaglandins to the systemic and renal vascular response to frusemide in normal man.

Mackay¹,

Muir²,

Watson³

1984

Brit J Clinical Pharma

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1 In eight normotensive male volunteers indomethacin decreased both the peak urine flow rate and total sodium excreted within 1 h of an intravenous dose of frusemide.2 Resting effective renal plasma flow and glomerular filtration rate were unchanged by indomethacin, but the increase in both parameters after frusemide was inhibited.3 The early increase in plasma renin activity after frusemide was inhibited by indomethacin. 4 Indomethacin decreased urinary excretion of PGE by 80% and the increase after frusemide was abolished. 5 The urinary excretion of a metabolite of systemic PGI2was unaltered in the 40-60 min period following frusemide.6 The early haemodynamic effects of frusemide are likely to be prostaglandin mediated, but there was no evidence of any change in systemic PGI2 synthesis after frusemide.

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Section: Prostaglandins and Frusemide 517mentioning

confidence: 99%

Contribution of prostaglandins to the systemic and renal vascular response to frusemide in normal man.

Mackay¹,

Muir²,

Watson³

1984

Brit J Clinical Pharma

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“…There was no significant differences of AUC, total plasma clearance, volume of distribution, and elimination half life between the two treatments. The amount of furosemide delivered into the urine is more directly related to response than is serum concentration of furosemide (14). Urine furosemide excretions between the two treatments were not different.…”

Section: Pharmacodynamic Datamentioning

confidence: 77%

Does Albumin Preinfusion Potentiate Diuretic Action of Furosemide in Patients with Nephrotic Syndrome?

Han

Kim

et al. 2001

J Korean Med Sci

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The aim of this cross-over study was to investigate whether albumin infusion before furosemide administration could potentiate the diuretic action of furosemide. Seven patients with nephrotic syndrome were given the following infusions in random order on two separate days: 1) a sham solution followed by 160 mg of furosemide, 2) 100 ml of 20% human albumin followed by 160 mg of furosemide. Urine and serum furosemide concentrations were measured by high-performance liquid chromatography. The increment of urine volume was greater in albumin preinfusion than in furosemide alone. However, the increments of sodium and chloride excretions between furosemide alone and albumin preinfusion were not different. No significant differences in the pharmacokinetic parameters between the two treatments were observed: area under the concentration-time curve (AUC: 12.7+/-2.2 vs 15.1+/-4.4 g/ml hr), total plasma clearance (253+/-41 vs 256+/-54 ml/min), volume of distribution (341+/-34 vs 494+/-153 ml/kg), elimination half life (4.0+/-1.1 vs 4.6+/-0.8 hr), and urine furosemide excretion of the administered amount (16.5+/-7.3 vs 7.5+/-1.6%). In conclusion, these data show that albumin preinfusion potentiated diuresis, but not natriuresis, of furosemide without any change in the pharmacokinetics of the agent in patients with nephrotic syndrome.

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“…Since probenecid decreases the clearance and increases the half-life of frusemide in man (Homeida et al, 1977;Honari et al, 1977;Chennavasin et al, 1979) and as the two drugs are quite often given together in clinical practice, the extent to which probenecid affects the diabetogenic action of frusemide in human patients remains to be examined.…”

Section: Discussionmentioning

confidence: 99%

“…Pretreatment with probenecid abolishes the diuretic response to frusemide in dogs (Hook & Williamson, 1965) and in cats (Friedman & Roch-Ramel, 1977). In humans, pretreatment with probenecid decreases renal and non-renal clearance of frusemide (Homeida et al, 1977;Honari et al, 1977;Chennavasin et al, 1979) with an increase in the plasma concentration and half-life of the drug (Homeida et al, 1977;Honari et al, 1977).…”

Section: Introductionmentioning

confidence: 99%

Probenecid potentiates the hyperglycaemic effect but reduces the diuretic effect of frusemide in mice

Sandström

1986

British J Pharmacology

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1 The effect of probenecid on frusemide-induced diuresis and hyperglycaemia was studied in mice. 2 Probenecid, a known inhibitor of tubular secretion of organic anions in the kidney, strongly reduced the diuretic response to frusemide (25 or 200 mg kg-' body weight). This effect of probenecid appeared to be dose-dependent up to 240 mg kg-' body weight, at least at the lower concentration of frusemide. 3 Pretreatment with probenecid (240 mg kg-' body weight) potentiated the hyperglycaemic effect of frusemide (25 or 200 mg kg-' body weight). 4 The results show that probenecid has opposite effects on frusemide-induced diuresis and hyperglycaemia in mice. It is suggested that the acute hyperglycaemic effect of frusemide is not directly linked to diuresis.

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Pharmacodynamic analysis of the furosemide-probenecid interaction in man

Cited by 140 publications

References 24 publications

Contribution of prostaglandins to the systemic and renal vascular response to frusemide in normal man.

Contribution of prostaglandins to the systemic and renal vascular response to frusemide in normal man.

Does Albumin Preinfusion Potentiate Diuretic Action of Furosemide in Patients with Nephrotic Syndrome?

Probenecid potentiates the hyperglycaemic effect but reduces the diuretic effect of frusemide in mice

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