Pharmacodynamic material basis of traditional Chinese medicine based on biomacromolecules: a review

Zhang, Wenjin; Wang, Sheng; Kang, Chuan-Zhi; Lv, Chaogeng; Zhou, Li; Huang, Luqi; Guo, Lan-Ping

doi:10.1186/s13007-020-00571-y

Cited by 48 publications

(26 citation statements)

References 111 publications

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“…If the spleen is healthy, the other four viscera are healthy, and the melancholia resolves itself. The Chinese traditional incense consisting mainly of AR, Phellodendri Chinensis Cortex, and Artemisiae Argyi Folium has demonstrated the advantages of Chinese medicine in “avoid poisonous gas” in the prevention of the novel coronavirus COVID-19 ( Zhang et al, 2020 ). “AR could warm the stomach, transport food and increase appetite” when combined with Galli Gigerii Endothelium Corneum, and it can promote appetite and increase the effect of Galli Gigerii Endothelium Corneum on relieving food and guiding stagnation ( Tao, 2013 ).…”

Section: Traditional Usesmentioning

confidence: 99%

“…A putative sesquiterpenoid biosynthetic pathway was proposed, including mevalonate, 2-C-methyl-d-erythritol-4-phosphate, sesquiterpene synthase, cytochrome P450, and the peroxisome pathway ( Chen et al, 2017 ). However, increasing studies showed that macromolecular substances (e.g., polysaccharides and proteins) play an indispensable role in the quality formation of TCM ( Zhang et al, 2020 ). The biomacromolecules in AR have wide bioactivity-related efficacy but yet to be fully appreciated compared with small molecule components.…”

Section: Phytochemistrymentioning

confidence: 99%

“…In the case of the unclear material basis of TCM, the overall effect of fingerprint is better than that of individual index components in terms of quality control. In addition, biomacromolecules play considerable roles in Chinese medicine, as their biological activities are related to TCM efficacy and their biological functions of the relationship between primary metabolism and the quality formation of TCM ( Zhang et al, 2020 ). Understanding the functional properties and mechanisms of biological macromolecules could help demystify the drug properties and health benefits of TCM.…”

Section: Quality Controlmentioning

confidence: 99%

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Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control

Zhang

Zhao

Chang

et al. 2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance Atractylodis Rhizoma (AR), mainly includes Atractylodes lancea (Thunb.) DC. ( A. lancea ) and Atractylodes chinensis (DC.) Koidz. ( A. chinensis ) is widely used in East Asia as a diuretic and stomachic drug, for the treatment of rheumatic diseases, digestive disorders, night blindness, and influenza as it contains a variety of sesquiterpenoids and other components of medicinal importance. Aim of the review A systematic summary on the botany, traditional uses, phytochemistry, pharmacology, toxicology, and quality control of AR was presented to explore the future therapeutic potential and scientific potential of this plant. Materials and methods A review of the literature was performed by consulting scientific databases including Google Scholar, Web of Science, Baidu Scholar, Springer, PubMed, ScienceDirect, CNKI, etc. Plant taxonomy was confirmed to the database “The Plant List”. Results Over 200 chemical compounds have been isolated from AR, notably sesquiterpenoids and alkynes. Various pharmacological activities have been demonstrated, especially improving gastrointestinal function and thus allowed to assert most of the traditional uses of AR. Conclusions The researches on AR are extensive, but gaps still remain. The molecular mechanism, structure-activity relationship, potential synergistic and antagonistic effects of these components need to be further elucidated. It is suggested that further studies should be carried out in the aspects of comprehensive evaluation of the quality of medicinal materials, understanding of the “effective forms” and “additive effects” of the pharmacodynamic substances based on the same pharmacophore of TCM, and its long-term toxicity in vivo and clinical efficacy.

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Section: Traditional Usesmentioning

confidence: 99%

Section: Phytochemistrymentioning

confidence: 99%

Section: Quality Controlmentioning

confidence: 99%

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Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control

Zhang

Zhao

Chang

et al. 2021

Journal of Ethnopharmacology

Self Cite

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“…Bioactive small peptides are composed of 2–10 amino acids linked by peptide bonds. Studies have found that amino acids such as Trp, Tyr, Met, Gly, Cys, His, and Pro in the peptide chain can significantly improve the bioactivity [ 23 , 24 ]. In other words, compared with traditional chemotherapy drugs, small peptides have several advantages, such as high absorption, small size, well-defined signaling targets, and minimal toxicity.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Small Peptides of Marine Origin in Cancer Therapy

et al. 2021

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Cancer is one of the leading causes of death in the world, and antineoplastic drug research continues to be a major field in medicine development. The marine milieu has thousands of biological species that are a valuable source of novel functional proteins and peptides, which have been used in the treatment of many diseases, including cancer. In contrast with proteins and polypeptides, small peptides (with a molecular weight of less than 1000 Da) have overwhelming advantages, such as preferential and fast absorption, which can decrease the burden on human gastrointestinal function. Besides, these peptides are only connected by a few peptide bonds, and their small molecular weight makes it easy to modify and synthesize them. Specifically, small peptides can deliver nutrients and drugs to cells and tissues in the body. These characteristics make them stand out in relation to targeted drug therapy. Nowadays, the anticancer mechanisms of the small marine peptides are still largely not well understood; however, several marine peptides have been applied in preclinical treatment. This paper highlights the anticancer linear and cyclic small peptides in marine resources and presents a review of peptides and the derivatives and their mechanisms.

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“…Each materia medica contained many formulae, with each formula comprising a combination of herbal drugs. Among these, complex components including carbohydrates/polysaccharides (PS), proteins/peptides, glycolipids/ glycoproteins, lipids, together with their metabolic derivatives such as glycosides, amines, fatty acids, flavonoids, terpenoids, phenols, and alkaloids intimately interacted with each other and modulated biological responses of immune cells and the hosts (Li and Kan, 2017;Yu et al, 2018b;Zhang et al, 2020c). Differential agonistic, compatible, or antagonistic interactions occur among TCM herbal ingredients.…”

Section: Introductionmentioning

confidence: 99%

Role of gut microbiota in identification of novel TCM-derived active metabolites

Lin

Lai

et al. 2020

Protein Cell

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Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and functions to maintain host homeostasis and health. Increasing evidences indicate that TCM herbs closely affect gut microbiota composition, which is associated with the conversion of herbal components into active metabolites. These may significantly affect the therapeutic activity of TCMs. Microbiota analyses, in conjunction with modern multiomics platforms, can together identify novel functional metabolites and form the basis of future TCM research.

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Pharmacodynamic material basis of traditional Chinese medicine based on biomacromolecules: a review

Cited by 48 publications

References 111 publications

Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control

Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control

Recent Advances in Small Peptides of Marine Origin in Cancer Therapy

Role of gut microbiota in identification of novel TCM-derived active metabolites

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