Pharmacodynamic Mechanism in Carcinogenesis

Combination Effects in Chemical Carcinogenesis (Experimental Results)

“…In view of the topicality of combination effects, especially the appraisal of these effects, it is rather remarkable that up to now relatively few investigators have been concerned with this problem. In this context, I would like to refer to the literature [e. g. Deichmann et al 1967, 1969, Grundmann et al 1965, Hoch-Ligeti et al 1968, Cardesa et al 1973, as well as to the presentation of the problem in summary by Nakahara 1975]. In the evaluation of carcinogenic effects, particularly where determination of threshold values is concerned, it has to be considered that different carcinogens may have additive effects.…”