Pharmacodynamical Effects of Asarone and β-Asarone

Sharma, Jaiprakash; Dandiya, P. C.; Baxter, R.M.; Kandel, Stephen I.

doi:10.1038/1921299b0

Cited by 25 publications

(12 citation statements)

References 2 publications

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“…Yuan Zhi is the radix of Polygala tenuifolia Willd and contains polygalitol, tenuigenin, polygalasaponin, oligosaccharides [Yukinobu et al, 2004] and xanthone derivatives. Shi Chang-Pu is the rhizome of Acorus gramineus Solander (Araceae) and its volatile oil or asarone was shown to be the active component exhibiting anticonvulsive action or sedative and hypothermic effects [Sharma et al, 1961;Zanoli et al, 1998]. …”

Section: Introductionmentioning

confidence: 99%

Behavioral and biochemical effects of Kaixin‐San, a traditional Chinese medicinal empirical formula

Hu¹,

Liu²,

Guo³

et al. 2008

Drug Development Research

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Kaixin-San (KXS), a traditional Chinese medicine, has been used in the treatment of depression. The present study was undertaken to investigate the effects of an ethanolic extract of KXS (KXS-E) in mouse models of depression, the forced swim test (FST) and tail suspension test (TST). At doses of 500 mg/kg, KXS-E reduced the immobility time in the FST and TST in mice 30 min after treatment. The main monoamine neurotransmitters and their metabolites in mouse brain regions were also simultaneously determined by HPLC-ECD. KXS-E not only increased the concentrations of 5-HT and NE in whole brain, but also reduced the ratio of 5-HIAA/5-HT, slowing down 5-HT metabolism as compared with mice treated with vehicle1stress. In conclusion, KXS-E produced antidepressant-like effects in a mouse model with a mechanism of action that may involve increased 5-HT and NE in the mouse brain. Drug Dev Res 69: 267-271, 2008.

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Section: Introductionmentioning

confidence: 99%

Behavioral and biochemical effects of Kaixin‐San, a traditional Chinese medicinal empirical formula

Hu¹,

Liu²,

Guo³

et al. 2008

Drug Development Research

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“…a-Asarone has attracted widespread interest recently for its use as a potential antithrombotic, antimicrobial, insecticidal, nematicidal and antifeedant agent. 27) In addition, animal studies have demonstrated various pharmacological characteristics of a-asarone in the nervous system, such as an anticonvulsive action 28) or sedative and hypothermic effects. 29,30) Moreover, Hu et al found that a-asarone at a dose of 48 mg/kg intraperitoneally (i.p.)…”

Section: Effects Of Acute Treatment With A-asarone On Li-pilomentioning

confidence: 99%

Anticonvulsant Activity of Acute and Chronic Treatment with a-Asarone from <i>Acorus gramineus</i> in Seizure Models

Chen

Miao

et al. 2013

Biological & Pharmaceutical Bulletin

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“…a-Asarone and b-asarone significantly enhanced the anesthetic activity of pentobarbitone, hexobarbitol, and ethanol in mice. b-Asarone appeared to be more active (Sharma et al, 1961). The mechanism of tranquilizing action of a-asarone was also studied.…”

Section: Cns Depressant Activitiesmentioning

confidence: 99%

“…It successfully prevented seizures in maximal electroshock seizures test (Khare & Sharma, 1982). b-Asarone caused generalized convulsion and potentiated metrazol seizures in rats, while a-asarone showed a tendency to protect against metrazol convulsions and modified electroshocks (Sharma et al, 1961). In a study using electroconvulsions, a-asarone increased the percentage mortality of animals treated with chlorpromazine but not of those treated with reserpine (Dandiya & Sharma, 1962;Dandiya & Menon, 1963).…”

Section: Anticonvulsant Activitymentioning

confidence: 99%

“…Bhattacharya, 1968;Bose et al, 1960;Dandiya et al, 1959a,b;Dandiya & Cullumbine, 1959;Dhalla & Bhattacharya, 1968;Malhotra et al, 1962 CNS depressant activities Essential oil, a-asarone, b-asarone, alcohol extract, aqueous extract Dandiya & Menon, 1964Menon & Dandiya. 1967;Sharma et al, 1961;Tripathi & Singh, 1995;Zanoli et al, 1998;Hazra & Guha, 2003 Anticonvulsant activity Essential oil, aqueous extract, alcohol extract, a-asarone Dandiya & Cullumbine, 1959;Dandiya & Menon, 1963;Dandiya & Sharma, 1962;Khare & Sharma, 1982;Madan et al, 1960;Manis et al, 1991;Sharma et al, 1961 Behavorial changes Essential oil, aqueous extract, alcohol extract, a-asarone Chak & Sharma, 1965;Dandiya et al, 1958;Dandiya & Cullumbine, 1959;…”

Section: Cns Depressant Activitiesmentioning

confidence: 99%

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Acorus calamus.: Scientific Validation of Ayurvedic Tradition from Natural Resources

Mukherjee

Venkatesan

Mal

et al. 2007

Pharmaceutical Biology

112

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Acorus calamus Linn. (Araceae), commonly known as ''sweet flag'' or ''calamus'', is a semiaquatic, perennial, aromatic herb with creeping rhizomes. The plant is found in the northern temperate and subtropical regions of Asia, North America, and Europe. The plant exhibits polyploidy. Many ethnomedicinal and ethnobotanical uses have been ascribed to the rhizomes of the plant. A. calamus Linn. (AC) has been used as traditional Chinese and Indian prescriptions for its beneficial effects on memory disorder, learning performance, lipid peroxide content, and anti-aging and anticholinergic activity. Moreover, pharmacological studies have revealed that Acorus rhizome and its constituents, particularly a-and b-asarone, possess a wide range of pharmacological activities such as sedative, CNS depressant, behavior modifying, anticonvulsant, acetylcholinesterase inhibitory, memory enhancing, anti-inflammatory, antioxidant, antispasmodic, cardiovascular, hypolipidemic, immunosuppressive, cytoprotective, antidiarrheal, antimicrobial, anthelmintic, insecticidal, adulticidal, diuretic, antioxidant, genotoxic, and mutagenic activities. This review is an effort to explore the different phytoconstituents and pharmacological activities of Acorus calamus.

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Pharmacodynamical Effects of Asarone and β-Asarone

Cited by 25 publications

References 2 publications

Behavioral and biochemical effects of Kaixin‐San, a traditional Chinese medicinal empirical formula

Behavioral and biochemical effects of Kaixin‐San, a traditional Chinese medicinal empirical formula

Anticonvulsant Activity of Acute and Chronic Treatment with a-Asarone from <i>Acorus gramineus</i> in Seizure Models

Acorus calamus.: Scientific Validation of Ayurvedic Tradition from Natural Resources

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