Pharmacodynamics and pharmacokinetics of AHR-11748, a new antiepileptic agent, in rodents

Johnson, D.; Osman, Mohamed A.; Cheng, Lawrence K.; Swinyard, Ewart A.

doi:10.1016/0920-1211(90)90037-v

Cited by 5 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the various derivatives of azetidines, 3-substitutedazetidine is most important constituent in various therapeutic potential moieties . Especially, 1-benzhydrylazetidin-3-ol ( N -(diphenylmethyl)-3-azetidinol), 1 is a useful pharmaceutical intermediate which has been widely used in the synthesis of Dezinamide (antiepileptic drug), Azelnidipine (antihypertensive drug), D83-7676 (an oncolytic drug), azetidinyloxy analogues (antimicrobial agents), oral carbapenem antibiotics such as tebipenem (LJC-11,036), tebipenem pivoxil (L-084), and various 3-substituted azetidine derivatives (Figure ).…”

Section: Introductionmentioning

confidence: 99%

Improved Process for the Preparation of 1-Benzhydrylazetidin-3-ol: Development of an Efficient Synthesis and Identification of Process-related Impurities and/or Intermediates

Reddy¹,

Babu²,

Ganesh³

et al. 2010

Org. Process Res. Dev.

View full text Add to dashboard Cite

An improved, one-pot, and multikilogram-scale synthesis of 1-benzhydrylazetidin-3-ol, the pharmaceutically important moiety, has been developed. The improved process for the preparation of 1-benzhydrylazetidin-3-ol was able to minimize a content of impurities and allows the effective production of 1-benzhydrylazetidin-3-ol and its scale-up. The process was high yielding (80%) and chromatography-free with purity 99.3 area %.

show abstract

Section: Introductionmentioning

confidence: 99%