Pharmacodynamics of amoxicillin against Mannheimia haemolytica and Pasteurella multocida and pharmacokinetic/pharmacodynamic (PK/PD) correlation in sheep

Delis, Georgios; Koutsoviti-Papadopoulou, M.; Siarkou, Victoria I.; Kounenis, G.; Batzias, Georgios

doi:10.1016/j.rvsc.2010.03.018

Cited by 11 publications

(8 citation statements)

References 47 publications

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“…In a recent PK/PD study of a depot formulation of amoxicillin in calves against bovine respiratory pathogens, Mannheimia haemolytica and Pasteurella multocida, it was stated that for sustained-release formulations a concentration-dependent action would better fit according to the time-kill data obtained [ 29 ]. Similar results were found in sheep against Mannheimia haemolytica and Pasteurella multocida isolates for amoxicillin [ 30 ]. Additionally, it has been reported that for drugs like the β-lactams, where efficacy has been found to be correlated to the T > MIC, the best PK/PD index shifts towards AUC/MIC dependence as half-life increases [ 31 ].…”

Section: Discussionsupporting

confidence: 80%

Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-LA administration in lactating goats

et al. 2016

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BackgroundBacterial pneumonia in goats is usually caused by Mannheimia haemolytica and Pasteurella multocida. Another important infection disease in lactating goats is intramammary infection producing mastitis, usually associated with coagulase-negative Staphylococcus spp. However, treatment of bacterial pneumonia in goats not affected by mastitis problems should be restricted to antimicrobials with scant penetration to milk in order to avoid long withdrawal times. Ceftiofur is a third-generation cephalosporin antimicrobial with activity against various gram-positive and gram-negative, aerobic and anaerobic bacteria encountered by domestic animals. The objectives of the present study were to establish the serum concentration–time profile for ceftiofur in lactating goats after intravenous, subcutaneous and a SC-long-acting ceftiofur formulation; to determine ceftiofur penetration into milk; to determine in vitro and ex vivo activity of ceftiofur establishing MIC, MBC, MPC and time-kill profiles against field strains of M. haemolytica and finally to calculate the main surrogate markers of efficacy.ResultsThe pharmacokinetics studies revealed an optimal PK properties for the SC-LA formulation tested. Ceftiofur was well absorbed following SC and SC-LA administration, with absolute bioavailabilities (F) of 85.16 and 84.43 %, respectively. After ceftiofur analysis from milk samples, no concentrations were found at any sampling time. The MIC, MBC and MPC data of ceftiofur against five M. haemolytica strains isolated from goats affected by pneumonia were tested showing excelent sensitivity of ceftiofur against this pathogen. For PK-PD analysis, ratios were calculated suggesting a high level of bacterial kill against the five strains of M. haemolytica tested.ConclusionsThe systemic ceftiofur exposure achieved in lactating goats following IV, SC and especially with the SC-LA administration is consistent with the predicted PK-PD ratios needed for a positive therapeutic outcome for M. haemolytica. Subcutaneous administration of the long-acting formulation showed safety and tolerance for all the animals used. Ceftiofur concentrations exceeded the MIC and MBC for up to 72 h and MPC for up 32 h in serum. Thus, this drug could be effective in treating infectious diseases of goats caused by M. haemolytica at a dose of 6 mg/kg with the SC-LA formulation.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-016-0863-9) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 80%

Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-LA administration in lactating goats

et al. 2016

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“…The PKPD model approach has been applied to a number of dosing regimens in livestock, including the use of danofloxacin in calves (228,240) and turkeys (104), enrofloxacin in poultry (105,214,253), oxytetracycline dose rates in sheep (246), oxytetracycline residues in sheep (51), amoxicillin in sheep (57), and colistin in pigs (101). In several cases the PKPD model was able to demonstrate the benefits of changes in dosing regimens.…”

Section: Pharmacokinetic-pharmacodynamic Modelsmentioning

confidence: 99%

Use of antimicrobial agents in livestock

Page¹,

Gautier²

2012

Rev. Sci. Tech. OIE

197

181

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Antimicrobial agents, especially antibacterial agents, are used throughout the world, across a diverse array of extensive and intensive livestock production systems, to protect the health and welfare of livestock and to improve their performance. While some agents that are used in livestock belong to classes that have no counterpart in human medicine, this is not the case for the most widely used agents: the tetracyclines, penicillins, macrolides and sulphonamides. Many bacterial diseases of livestock cause devastating losses of animal life and productivity. As a result, their keepers can lose their livelihoods and see a dramatic reduction in income, so there is often a great sense of urgency to treat affected animals early. However, there are a large number of bacterial pathogens that cause disease and it is frequently difficult to reach a conclusive diagnosis prior to instituting treatment. There are many ways in which existing uses of antimicrobial agents can be improved, amongst the most important are increased utilisation of veterinary professional services, the introduction of enhanced infection control measures, improved point-of-care diagnostic tests, and the application of physiologically based population pharmacokinetic-pharmacodynamic modelling.

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“…It not only possesses antimicrobial activity against most gram-positive and gram-negative bacteria as other β-lactam antibiotics, but also presents higher absorption rate than other β-lactam antibiotics in humans and animals [1][2][3]. Thus, it is usually used for the treatment of infectious diseases caused by these bacteria in humans and animals, and remained in biological fluids and animals food production.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer grown on multiwalled carbon nanotube surface for the sensitive electrochemical determination of amoxicillin

Yang

Zhao

2015

Electrochimica Acta

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Pharmacodynamics of amoxicillin against Mannheimia haemolytica and Pasteurella multocida and pharmacokinetic/pharmacodynamic (PK/PD) correlation in sheep

Cited by 11 publications

References 47 publications

Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-LA administration in lactating goats

Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-LA administration in lactating goats

Use of antimicrobial agents in livestock

Molecularly imprinted polymer grown on multiwalled carbon nanotube surface for the sensitive electrochemical determination of amoxicillin

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