Pharmacoepidemiology of ascites and associated complications in hospitalized patients: descriptive observational study

Tasneem, Hirra; Shahbaz, Huda; Sherazi, Bushra Ali

doi:10.3329/icpj.v4i2.21482

Cited by 4 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liver cirrhosis was found to be the main cause of ascites in this study similar to other studies done elsewhere [10, 14–18]; however, the proportion of ascites caused by liver cirrhosis was lower as compared to the studies conducted in USA, Qatar, and Ethiopia [10, 15, 17]. This could be because of the higher tuberculosis and hepatosplenic schistosomiasis in the current study, where such infections are epidemic in the study setting.…”

Section: Discussionsupporting

confidence: 85%

“…Heart failure, tuberculosis, and hepatosplenic schistosomiasis were relatively more common in this study in contrast to studies done in the USA, Qatar, and Pakistan [10, 14, 15]. However, tuberculosis incidence (11.5%) in this study was lower in contrast to the study done in Nigeria (22%) but was comparable to a previous Ethiopian study (9%).…”

Section: Discussioncontrasting

confidence: 81%

“…Malignant related ascites was lower (in 2 patients) in this study in contrast to the studies done in Pakistan, Qatar, and Nigeria [14–16]. This is probably due to the younger age of the participants in this study where the majority of the participants are younger than 50 years of age.…”

Section: Discussioncontrasting

confidence: 76%

See 2 more Smart Citations

Causes and Clinical Profiles of Ascites at University of Gondar Hospital, Northwest Ethiopia: Institution-Based Cross-Sectional Study

Muhie

2019

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

Background. Ascites is a common clinical condition encountered by physicians in day-to-day practice. It is caused by various underlying diseases. Knowing the etiologies is vital because further investigations and definitive treatment largely rely on the specific disease entity considered. Objective. The aim of this study was to determine the epidemiology of causes of ascites and complications among patients with ascites from the medical department at the University of Gondar Hospital. Methods. Data on sociodemography, major symptoms, and signs, risk factors, past medical illnesses, and results of important investigations were collected using pretested questionnaires among all patients with ascites in the University of Gondar Hospital in a sample size of 52. Data were collected by well-trained physicians and analyzed by using SPSS 16. Results were depicted descriptively with measures of central tendency, dispersion, and using tables and graphs. Results. A total of 52 patients were included in this study from November 1, 2018 to March 30, 2019. Thirty (57.7%) of them were males and the majority (77%) of the participants were fifty years old or younger. The mean age was 43.8 (± 14). The majority (86.5%) of the participants were from a rural area. Thirty-eight (73%) patients take alcohol occasionally while 11(21.2%) patients take alcohol frequently or massively. Eight (15.4%) patients reported a history of multiple sexual partners. Herbal medicine use was reported by 28 patients (53.8%). Only 5 (9.6%) patients were overweight. Chronic liver disease (CLD) was the major cause of ascites in this study in 24 (46.2%) patients. The other main causes of ascites were heart failure from various causes (19.2%), tuberculosis and hepatosplenic schistosomiasis contributing to 11.5% each and chronic kidney disease (5.8%). Five (20.8%) CLD patients had spontaneous bacterial peritonitis as a complication. Five (20.8%) and 4 (16.7%) CLD patients had hepatocellular carcinoma and hepatic encephalopathy as complications, respectively. Nine (17.3%) patients had variceal bleeding; six of the patients were diagnosed to have CLD while the remaining patients were having hepatosplenic schistosomiasis. Conclusion. In conclusion, liver cirrhosis is the major cause of ascites in Gondar, Ethiopia, while chronic viral hepatitis infections (hepatitis B (HBV) and C (HCV) viruses) are the main causes of liver cirrhosis. The other major causes included heart failure, tuberculosis, and hepatosplenic schistosomiasis. It is wise to consider and give priority to these diseases whenever one is evaluating a patient with ascites.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussioncontrasting

confidence: 81%

See 1 more Smart Citation

Causes and Clinical Profiles of Ascites at University of Gondar Hospital, Northwest Ethiopia: Institution-Based Cross-Sectional Study

Muhie

2019

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

show abstract

“…This is comparable with other studies conducted in Africa and in the Western world. 1,2,5,[11][12] For instance, these findings are similar to a study conducted in Nigeria which showed similar aetiologies of ascites. 11 However, patients in the Nigeria study had a lower prevalence of liver cirrhosis (44%), and high percentages of tuberculous peritonitis (23%) and malignant ascites (22%).…”

Section: Discussionsupporting

confidence: 82%

Causes Of Ascites And Its Correlation With Serum-Ascites Albumin Gradient In Patients Admitted At Medical Wards In A Tertiary Hospital In Ghana.

Duah,

Agyei-Nkansah,

Duah

et al. 2022

gcps

View full text Add to dashboard Cite

Objective: Ascites can be classified depending on whether it results from portal hypertension (PH) or non-portal hypertension (NPH) causes. This classification is relevant because the modes of evaluation and management are different for these two groups. Serum-ascites albumin gradient (SAAG) has been proposed in many studies to categorise ascites better than ascetic fluid total protein. This has not been determined in Ghanaian patients with ascites. The aim of this study was to determine the aetiology of ascites and to assess the performance of SAAG in the classification of portal versus non-portal hypertension ascites among patients admitted to a tertiary hospital in Ghana. Methodology: A cross-sectional study was conducted at the Korle-Bu Teaching hospital, where 140 patients with ascites were recruited within the study period. Data on socio-demography, clinical features, and results of relevant laboratory investigations and imaging studies were collected using pretested questionnaires Results: The mean age of patients was 44.7±13.2 years. Chronic liver disease (CLD) was the major cause of ascites in this study representing 73.57%. SAAG had a sensitivity of 91.59%, positive predictive value of 95.15% and diagnostic accuracy of 90.0% in classifying ascites as due to a PH or NPH. Conclusion: CLD was the major cause of ascites in Ghanaian patients. SAAG has satisfactory diagnostic accuracy in differentiating ascites related to PH from NPH causes. This could be used as a first line investigation in the aetiological diagnosis of ascites for initiation of prompt treatment.

show abstract

“…Examples of mixed ascites include liver cirrhosis plus peritoneal carcinomatosis, peritoneal tuberculosis, heart failure or renal failure and liver cirrhosis plus heart failure and diabetic nephropathy. In the latter case, cirrhosis complicates non-alcoholic steatohepatitis 11 .…”

Section: Introductionmentioning

confidence: 99%

Frequency and characterization of mixed ascites among cirrhotic patients admitted to Zagazig University hospital

Ibrahim

Elsaid

Dina

et al. 2020

Medical Journal of Viral Hepatitis

View full text Add to dashboard Cite

Background and aim. Mixed ascites is defined in patients in whom two or more etiologies of ascites are demonstrated. Such patients have liver cirrhosis plus (an) other local and/or systemic cause(s). The aim of this work is to detect the frequency and characterization of mixed ascites among cirrhotic patients. Patients and methods.The study was conducted on 273 ascitic cirrhotic patients. All patients were subjected to full history taking, thorough clinical examination, radiological investigations and laboratory investigations including CRP and tumor markers (AFP, CEA, CA 19-9, CA 125). Diagnostic abdominal paracentesis with cytologic and biochemical analyses and Ziehl-Neelsen staining of ascitic fluid were done. Also, serum-ascites albumin gradient (SAAG) was calculated. Results. Twenty eight patients (10.3%) among the studied patients were mixed ascites. Among patients with mixed ascites, the most common cause was malignancy in 11 patients (39.2%), cardiac causes were present in 7 patients (25%), renal causes were found in 2 patients (7.1%) and surgical abdominal causes were present in 8 patients (28.7%). Compared to non-mixed ascites, patients with mixed ascites had a statistically significant increase regarding ascitic total leucocytic count, lactate dehydrogenase and protein. Moreover, there was a significant increase in tumor markers and CRP in patients with mixed ascites versus patients with non-mixed ascites. Using logistic regression analysis, the predictor variables for mixed ascites in cirrhotic patients included positive tumor markers CEA and CA 19-9 and positive CRP. Conclusion. in our study, the commonest cause of mixed ascites was malignancy. Significant predictors of mixed ascites were CRP and tumor markers; CEA, CA 19-9 and CA 125.

show abstract

Pharmacoepidemiology of ascites and associated complications in hospitalized patients: descriptive observational study

Cited by 4 publications

References 15 publications

Causes and Clinical Profiles of Ascites at University of Gondar Hospital, Northwest Ethiopia: Institution-Based Cross-Sectional Study

Causes and Clinical Profiles of Ascites at University of Gondar Hospital, Northwest Ethiopia: Institution-Based Cross-Sectional Study

Causes Of Ascites And Its Correlation With Serum-Ascites Albumin Gradient In Patients Admitted At Medical Wards In A Tertiary Hospital In Ghana.

Frequency and characterization of mixed ascites among cirrhotic patients admitted to Zagazig University hospital

Contact Info

Product

Resources

About