Pharmacogenetic Testing in Schizophrenia and Posttraumatic Stress Disorder

Ramey-Hartung, Bronwyn; El-Mallakh, Rifaat S.; Reynolds, Kristen K.

doi:10.1016/j.cll.2008.08.004

Cited by 2 publications

(1 citation statement)

References 109 publications

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“…The identification of particular environmental risk factors, geno-types, or gene expression patterns specific to trauma exposure and PTSD may dictate which treatment regimens will be most effective for a particular patient. An area of increasing interest to mental health clinicians is pharmacogenetics in which the goal is to genotype patients before starting a particular psychiatric pharmacological therapy as a means of determining a patient’s likelihood of a therapeutic response,134 Further, the identification of potential genetic variants that increase susceptibility for developing psychiatric illness would be a particularly important tool for advancing treatment options for PTSD and related anxiety disorders.…”

Section: Tailoring Individual Treatment Plans For Ptsd: Future Directmentioning

confidence: 99%

Tailoring therapeutic strategies for treating posttraumatic stress disorder symptom clusters

Norrholm

Jovanović²

2010

NDT

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According to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, posttraumatic stress disorder (PTSD) is characterized by three major symptom clusters following an event that elicited fear, helplessness, or horror. This review will examine each symptom cluster of PTSD separately, giving case study examples of patients who exhibit a preponderance of a given symptom domain. We use a translational approach in describing the underlying neurobiology that is relevant to particular symptoms and treatment options, thus showing how clinical practice can benefit from current research. By focusing on symptom clusters, we provide a more specific view of individual patient’s clinical presentations, in order to better address treatment needs. Finally, the review will also address potential genetic approaches to treatment as another form of individualized treatment.

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Section: Tailoring Individual Treatment Plans For Ptsd: Future Directmentioning

confidence: 99%