Pharmacogenetic Testing or Therapeutic Drug Monitoring: A Quantitative Framework
Maddalena Centanni,
Niels Reijnhout,
Abel Thijs
et al.
Abstract:Background
Pharmacogenetic profiling and therapeutic drug monitoring (TDM) have both been proposed to manage inter-individual variability (IIV) in drug exposure. However, determining the most effective approach for estimating exposure for a particular drug remains a challenge. This study aimed to quantitatively assess the circumstances in which pharmacogenetic profiling may outperform TDM in estimating drug exposure, under three sources of variability (IIV, inter-occasion variability [IOV], and re… Show more
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