Pharmacogenetics of Cancer and DNA Repair Enzymes

Straaten, Tahar van der; Mullenders, Leon H.F.; Guchelaar, Henk‐Jan

doi:10.5772/23338

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General Mechanism Of Action For Cisplatin1

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2014

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References 77 publications

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“…Once in the cell, cisplatin becomes aquated and positively charged. It is then able to interact with and intercalate tumor DNA, forming cross-links and unwinding the helix; such DNA damage results in inhibition of DNA replication, eventually triggering apoptosis and necrosis ( Figure 1 ) [7,8] . Platinating agents can form four types of links on DNA, i.e.…”

Section: General Mechanism Of Action For Cisplatinmentioning

confidence: 99%

Pharmacogenomics of Cisplatin Sensitivity in Non-Small Cell Lung Cancer

Rose

Kostyanovskaya

Huang

2014

Genomics, Proteomics &Amp; Bioinformatics

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Cisplatin, a platinum-based chemotherapeutic drug, has been used for over 30 years in a wide variety of cancers with varying degrees of success. In particular, cisplatin has been used to treat late stage non-small cell lung cancer (NSCLC) as the standard of care. However, therapeutic outcomes vary from patient to patient. Considerable efforts have been invested to identify biomarkers that can be used to predict cisplatin sensitivity in NSCLC. Here we reviewed current evidence for cisplatin sensitivity biomarkers in NSCLC. We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways. Current evidence suggests that cisplatin-based treatment could be improved by the use of these biomarkers.

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Section: General Mechanism Of Action For Cisplatinmentioning

confidence: 99%