Pharmacogenetics of human sulfotransferases and impact of amino acid exchange on Phase II drug metabolism

Isvoran, Adriana; Peng, Yunhui; Ceauranu, Silvana; Schmidt, Leon; Nicot, Arnaud

doi:10.1016/j.drudis.2022.103349

Cited by 22 publications

(9 citation statements)

References 120 publications

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“…NALP7 regulates innate immune responses by promoting the maturation of the inflammatory cytokines IL-1β and IL-18. ST1A1 (SULT1A1) is a sulfotransferase that catalyzes the sulfation of catecholamines, estrogens, phenolics, and neurotransmitters and plays a crucial role in phase II drug metabolism ( Isvoran et al, 2022 ). ST1A1, like STAMBP, is down-regulated during late pregnancy in women with postpartum depression ( Bränn et al, 2017 ) and is associated with an increased risk of esophageal squamous cell carcinoma ( Aversa et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Olink proteomics profiling platform reveals non-invasive inflammatory related protein biomarkers in autism spectrum disorder

Bao

Chen

et al. 2023

Front. Mol. Neurosci.

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BackgroundOwing to the lack of valid biomarkers, the diagnosis of autism spectrum disorder (ASD) diagnosis relies solely on the behavioral phenotypes of children. Several researchers have suggested an association between ASD and inflammation; however, the complex relationship between the two is unelucidated to date. Therefore, the current study aims to comprehensively identify novel circulating ASD inflammatory biomarkers.MethodsOlink proteomics was applied to compare the plasma inflammation-related protein changes in a group of the healthy children (HC, n = 33) and another with ASD (n = 31). The areas under the receiver operating characteristic curves (AUCs) of the differentially expressed proteins (DEPs) were calculated. The functional analysis of the DEPs was performed using Gene Ontology and Kyoto Encyclopedia Genes and Genomes. Pearson correlation tests were used employed to analyze the correlation between the DEPs and clinical features.ResultsA total of 13 DEPs were significantly up-regulated in the ASD group compared with the HC group. The four proteins, namely, STAMBP, ST1A1, SIRT2, and MMP-10 demonstrated good diagnostic accuracy with the corresponding AUCs (95% confidence interval, CI) of 0.7218 (0.5946–0.8489), 0.7107 (0.5827–0.8387), 0.7016 (0.5713–0.8319), and 0.7006 (0.568–0.8332). Each panel of STAMBP and any other differential protein demonstrated a better classification performance [AUC values from 0.7147 (0.5858–0.8436, STAMBP/AXIN1) to 0.7681 (0.6496–0.8867, STAMBP/MMP-10)]. These DEP profiles were enriched in immune and inflammatory response pathways, including TNF and NOD-like receptor signaling pathways. The interaction between STAMBP and SIRT2 (R = 0.97, p = 8.52 × 10−39) was found to be the most significant. In addition, several DEPs related to clinical features in patients with ASD, particularly AXIN1 (R = 0.36, p = 0.006), SIRT2 (R = 0.34, p = 0.010) and STAMBP (R = 0.34, p = 0.010), were positively correlated with age and parity, indicating that older age and higher parity may be the inflammation-related clinical factors in ASD.ConclusionInflammation plays a crucial role in ASD, and the up-regulated inflammatory proteins may serve as potential early diagnostic biomarkers for ASD.

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Section: Discussionmentioning

confidence: 99%

Olink proteomics profiling platform reveals non-invasive inflammatory related protein biomarkers in autism spectrum disorder

Bao

Chen

et al. 2023

Front. Mol. Neurosci.

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“…It has characteristic fragment ions of dopamine at m/z 137.0595 and 154.0855 and a typical neutral loss of 80 Da indicative of a sulfate conjugate. [4,40] It was found in plasma and urine samples from BOKA-T and TOAST (Figure 3). K20 and K21 are likely to be derived from dopamine but further annotation was not possible.…”

Section: Dopamine Metabolitesmentioning

confidence: 99%

Human Metabolism and Excretion of Kawakawa (Piper excelsum) Leaf Chemicals

Jayaprakash,

Pook,

Ramzan

et al. 2024

Molecular Nutrition Food Res

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ScopePiper excelsum (kawakawa) has a history of therapeutic use by Māori in Aotearoa New Zealand. It is currently widely consumed as a beverage and included as an ingredient in “functional” food product. Leaves contain compounds that are also found in a wide range of other spices, foods, and medicinal plants. This study investigates the human metabolism and excretion of kawakawa leaf chemicals.Methods and resultsSix healthy male volunteers in one study (Bioavailability of Kawakawa Tea metabolites in human volunteers [BOKA‐T]) and 30 volunteers (15 male and 15 female) in a second study (Impact of acute Kawakawa Tea ingestion on postprandial glucose metabolism in healthy human volunteers [TOAST]) consume a hot water infusion of dried kawakawa leaves (kawakawa tea [KT]). Untargeted Liquid Chromatography‐Tandem Mass spectrometry (LC‐MS/MS) analyses of urine samples from BOKA‐T identified 26 urinary metabolites that are significantly associated with KT consumption, confirmed by the analysis of samples from the independent TOAST study. Seven of the 26 metabolites are also detected in plasma. Thirteen of the 26 urinary compounds are provisionally identified as metabolites of specific compounds in KT, eight metabolites are identified as being derived from specific compounds in KT but without resolution of chemical structure, and five are of unknown origin.ConclusionsSeveral kawakawa compounds that are also widely found in other plants are bioavailable and are modified by phase 1 and 2 metabolism.

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“… 44 Such polymorphisms might be crucial for interindividual variability in drug response and toxicity or for increased disease risk. 45 For example, SULT1A1 polymorphism is associated with an increased risk of some cancers, such as breast cancer (especially in Asian patients), 46 gastric cancer, 47 tongue cancer in women, 48 and oral squamous cell carcinoma in Taiwanese patients with the H149Y haplotype. 49 CYP450s are critical in the stimulation of phase I drug metabolism 50 and detoxification as well as the elimination of common drugs.…”

Section: Adrs and Pharmacogenomicsmentioning

confidence: 99%

Structure–activity relationships and interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm

Thabet,

Alshar,

Alabdallah

et al. 2023

J Int Med Res

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Adverse drug reactions represent a major health burden because they cause notable patient morbidity and mortality. From this viewpoint, several strategies have been developed to prevent or reduce adverse drug reactions. One such strategy is the use of pharmacogenomics. Interindividual variability in drug response and adverse effects is mainly attributable to genetic variation in enzymes such as sulfotransferases and cytochrome P450s. The current narrative review discusses the relationship between the structure and activity of drugs. Specifically, the activity of drugs can be increased and/or their adverse effects can be reduced by altering specific positions in their structures.

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Pharmacogenetics of human sulfotransferases and impact of amino acid exchange on Phase II drug metabolism

Cited by 22 publications

References 120 publications

Olink proteomics profiling platform reveals non-invasive inflammatory related protein biomarkers in autism spectrum disorder

Olink proteomics profiling platform reveals non-invasive inflammatory related protein biomarkers in autism spectrum disorder

Human Metabolism and Excretion of Kawakawa (Piper excelsum) Leaf Chemicals

Structure–activity relationships and interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm

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