2022
DOI: 10.3390/jpm12020159
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Pharmacogenetics to Avoid Adverse Drug Reactions

Abstract: Although a cure is the main goal of a treatment, serious adverse reactions associated with these treatments are a major problem in clinical practice and cost a lot of money for health systems [...]

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“…The intricate orchestration of drug metabolism pivots upon the catalytic activity of diverse drug-metabolizing enzymes, among which the CYP2C19 gene assumes a pivotal role by encoding pivotal drug-metabolizing enzymes. 32 Given the extensive clinical utilization of drugs that undergo metabolism facilitated by the CYP2C19 enzyme, the scrutiny of CYP2C19 genotypes across different geographical regions and ethnic strata has assumed paramount importance. This trajectory of investigation offers a compass for prognosticating patient metabolic phenotypes and furnishing guidance for clinical drug administration.…”
Section: Discussionmentioning
confidence: 99%
“…The intricate orchestration of drug metabolism pivots upon the catalytic activity of diverse drug-metabolizing enzymes, among which the CYP2C19 gene assumes a pivotal role by encoding pivotal drug-metabolizing enzymes. 32 Given the extensive clinical utilization of drugs that undergo metabolism facilitated by the CYP2C19 enzyme, the scrutiny of CYP2C19 genotypes across different geographical regions and ethnic strata has assumed paramount importance. This trajectory of investigation offers a compass for prognosticating patient metabolic phenotypes and furnishing guidance for clinical drug administration.…”
Section: Discussionmentioning
confidence: 99%