Pharmacogenetics: uncovering the complex relationship between HIV and non-adherence among South African breast cancer patients treated with tamoxifen

Nthontho, Keneuoe C; Tawe, Leabaneng; Paganotti, Giacomo Maria

doi:10.1007/s10549-023-06913-3

Cited by 1 publication

(1 citation statement)

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“…HIV-positive women who are diagnosed with breast cancer have a lower survival rate than their HIV-negative counterparts [ 62 ]. It is postulated that for women in the HIV-positive group, increased drug toxicity and drug-drug interactions while being treated for breast cancer lead to poorer outcomes compared to their HIV-negative counterparts [ 63 , 64 ].…”

Section: Editorialmentioning

confidence: 99%

From Incidence to Intervention: A Comprehensive Look at Breast Cancer in South Africa

Dlamini,

Molefi,

Khanyile

et al. 2023

Oncol Ther

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The formidable impact of breast cancer extends globally, with South Africa facing pronounced challenges, including significant disparities in breast cancer screening, treatment and survival along ethnic and socioeconomic lines. Over the last two decades, breast cancer incidence has increased and now accounts for a substantial portion of cancers in women. Ethnic disparities in terms of screening, incidence and survival exacerbate the issue, leading to delayed diagnosis among Black patients and highlighting healthcare inequities. These concerning trends underscore the urgency of enhancing breast cancer screening while mitigating treatment delays, although obstacles within the healthcare system impede progress. The intersection of breast cancer and human immunodeficiency virus (HIV) further complicates matters and particularly affects the Black population. Tackling the aforementioned disparities in breast cancer in South Africa mandates a multifaceted strategy. Robust screening efforts, particularly those targeting marginalised communities, are crucial for early detection. Concurrently, expedited treatment initiation is imperative. Addressing HIV-related complexities requires tailored interventions to ensure effective care. These multifaceted disparities require pan African research and cooperation as well as tailored interventions to enhance breast cancer care within the African region.

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Section: Editorialmentioning

confidence: 99%