Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy

Kuete, Victor; Efferth, Thomas

doi:10.1016/j.jep.2011.06.035

Cited by 82 publications

(36 citation statements)

References 85 publications

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“…In general, leukemia cells are clinically more sensitive to chemotherapy than tumors [18, 19]. In the present study we focused on carcinoma cells involved in lung, colon, breast and liver cancers.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells

Kuete

Omosa

Tala

et al. 2016

BMC Pharmacol Toxicol

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BackgroundCancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases.MethodsThis study was designed to investigate the cytotoxicity of 14 naturally occurring quinones including; 3 anthraquinones, 1 naphthoquinone and 10 benzoquinones against 6 human carcinoma cell lines and normal CRL2120 fibroblasts. The neutral red uptake (NR) assay was used to evaluate the cytotoxicity of the compounds, whilst caspase-Glo assay was used to detect caspases activation. Cell cycle and mitochondrial membrane potential (MMP) were all analyzed via flow cytometry meanwhile levels of reactive oxygen species (ROS) were measured by spectrophotometry.ResultsAnthraquinone: emodin (2), naphthoquinone: plumbagin (4), and benzoquinones: rapanone (9), 2,5-dihydroxy-3-pentadecyl-2,5-cyclohexadiene-1,4-dione (10), 5-O-methylembelin (11), 1,2,4,5-tetraacetate-3-methyl-6-(14-nonadecenyl)-cyclohexadi-2,5-diene (13), as well as doxorubicin displayed interesting activities with IC50 values below 100 μM in the six tested cancer cell lines. The IC50 values ranged from 37.57 μM (towards breast adenocarcinoma MCF-7 cells) to 99.31 μM (towards small cell lung cancer A549 cells) for 2, from 0.06 μM (MCF-7 cells) to 1.14 μM (A549 cells) for 4, from 2.27 μM (mesothelioma SPC212 cells) to 46.62 μM (colorectal adenocarcinoma DLD-1 cells) for 9, from 8.39 μM (SPC212 cells) to 48.35 μM (hepatocarinoma HepG2 cells) for 10, from 22.57 μM (MCF-7 cells) to 61.28 μM (HepG2 cells) for 11, from 9.25 μM (MCF-7 cells) to 47.53 μM (A549 cells) for 13, and from 0.07 μM (SPC212 cells) to 1.01 μM (A549 cells) for doxorubicin. Compounds 4 and 9 induced apoptosis in MCF-7 cells mediated by increased ROS production and MMP loss, respectively.ConclusionThe tested natural products and mostly 2, 4, 9, 10, 11 and 13 are potential cytotoxic compounds that deserve more investigations towards developing novel antiproliferative drugs against human carcinoma.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells

Kuete

Omosa

Tala

et al. 2016

BMC Pharmacol Toxicol

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“…The compound had been previously reported to possess anti-inflammatory as well as antiplatelet aggregation activities, which are complementary to the observed trypanocidal property. [144][145][146][147][148] Since inflammation poses major problems in the advanced stages of trypanosomiasis, compound 62 represents a promising natural hit with a reasonable selectivity for T. b. rhodesiense.…”

Section: Amidesmentioning

confidence: 99%

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Cv¹,

Ntie‐Kang²,

Sh.³

et al. 2018

Preprint

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An absolute configuration of 5R seems to decrease activity of the compound IntroductionProtozoa may be considered as microscopic, essentially single-celled, eukaryotic organisms that are free-living or parasitic (obtaining their food by eating other organisms or their products) in nature. Parasitic protozoal diseases continue to be a cause of considerable morbidity and mortality globally. 1,2Parasitic protozoal diseases include malaria, 3,4 trypanosomiasis (African sleeping sickness and Chagas disease), 5-7 leishmaniasis 8 and schistosomiasis. 9,10 They threaten almost one-third of the world's population, the most numerous incidents being recorded in over 100 Tropical and developing countries and territories, Figure 1. 11,12 Malaria, for example, was reported by the WHO, to be responsible for approximately 214 million sickness cases and 438,000 deaths globally in 2017. 13 The African region recorded the most death-related cases, especially amongst infants below the age of 5 and pregnant women. Schistosomiasis, caused by parasites of the Schistosoma genus are responsible for about 200 million sickness cases and about 280,000 death-related incidents annually worldwide.9,10,14 Only one drug (praziquantel) has been proven to be effective in the treatment of human schistosomiasis, with no vaccine available or in development so far.15-21 Serious concerns about drug selectivity and resistance were raised in 2013 when over 30 million people were treated in Sub-Saharan Africa. 20 Moreover, observed resistance and reduced efficiency of praziquantel in laboratory strains have prompted the search for alternative therapeutic strategies. Trypanosomiasis, which represents several diseases caused by parasites of the genus Trypanosoma, is also of interest. 5,27,29 This disease, which is much arguably the most important disease of man and domesticated animals, accounts for over 8 million reported annual cases globally, especially in the tropical regions of Latin America and Africa. 30,31 Although the present number of cases seems negligible on a worldwide scale, great socioeconomic effects on the endemic areas by this disease are forecast if inadequate attention (both at the communal, national, and international levels) is not given. 7,29,[32][33][34] Leishmaniasis is caused by parasites of the Leishmania type, which is also transmitted by certain types of sandflies. 35,36 The diseases are reported by the WHO to be responsible for about 1 million new cases leading to approximately 30,000 deaths annually on a global scale. The major cause is linked to environmental changes A R T I C L E I N F O A B S T R A C TArticle history:English abstract: Parasitic diseases continue represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug di...

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“…Six compounds such as four iridoids, fulvoplumierin, allamcin, allamandin and plumericin; 2,5-dimethoxy-p-benzoquinone and lignan liriodendrin were isolated from different extracts of the plants all showing toxicity to murine lymphocytic leukemia and various human cancer cell-lines (breast, colon, melanoma, lung, fibrosarcoma, KB) (Kardono et al, 1990). Plumericin from P. rubra, a Cameroonian traditional anticancerous plant was tested against 60 NCI cell lines and the probable mode of action was determined (Kuete and Efferth, 2011). Heartwood of the plant has produced plumericin, isoplumericin and 4-hydroxyacetophenone with cytotoxic efficacy (Hamburger et al, 1991).…”

Section: Pharmacologymentioning

confidence: 99%

Plumeria rubra L. (Apocynaceae): Ethnobotany, Phytochemistry and Pharmacology: A Mini Review

Dey¹,

Mukherjee²

2015

J. of Plant Sciences

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Plumeria rubra L. (Apocynaceae) is a deciduous ornamental tree species with fragrant flowers native to Mexico, Central America, Colombia and Venezuela but also cultivated in tropical and subtropical countries. The plant is known to possess biological activities viz., antibacterial, antifungal, antiviral, antialgal, larvicidal, molluscicidal, piscicidal, nematicidal, antioxidative and free radical scavenging, hypolipidemic, proteolytic, cytotoxic, abortifacient activities etc. A number of phyto-constituents are reported from the plant which signifies biological activities and diverse ethnomedicinal uses of this plant species. The present review deals with the literature involving ethnobotany, phytochemistry and pharmacology of the plant.Key words: Plumeria rubra, ethnobotany, phytochemistry, pharmacology, review INTRODUCTIONPlumeria rubra L. (Apocynaceae) commonly known as 'Frangipani' is an ornamental tree species bearing fragrant flowers. The plant is native to Mexico, Central America, Colombia and Venezuela but cultivated in tropical and subtropical countries. The plant is reportedly used in a number of traditional medicinal preparations throughout Asia and Latin America for diabetes, diarrhea, dysentery, intestinal worms, stomach-ache, toothache, earache, eye-cleaning, tongue cleaning, finger nail pain, wound healing, fractures, blisters, sores, subcutaneous mycosis, rabies, malaria, rheumatism, asthma, cancer, birth control, women complaints, lactation, pediatric care, ethnoveterinary (diarrhoea and dysentery and snakebite), piscicidal, offering to god and as ornamental and it is also utilized as part of folk ritual due to its aesthetic values. A number of preclinical pharmacological investigations were performed to elucidate its bioactivities such as antibacterial, antifungal, antiviral, antialgal, larvicidal, molluscicidal, piscicidal, nematicidal, antioxidative and free radical scavenging, hypolipidemic, proteolytic, anticancer, abortifacient properties. A number of phytochemicals have been isolated from the plant, a few of which were correlated with its bioactivity. A systematic compilation on ethnobotanical, phytochemical and pharmacological aspects has been given in this paper.

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Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy

Cited by 82 publications

References 85 publications

Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells

Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Plumeria rubra L. (Apocynaceae): Ethnobotany, Phytochemistry and Pharmacology: A Mini Review

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