Pharmacognostic Studies and Chromatographic Analysis of the Gum of Anacardium occidentale L (Anacardiaceae)

Dafam, D.G.; Nuhu, H.; Ohemu, T.L.; Olotu, PN; Kagaru, D.C.; Abubakar, .

doi:10.7324/japs.2014.40210

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…All the water absorptive parameters (except distilled water) increased with increasing pH of the medium, suggesting disintegration and drug retention functional potentials of this gum when present in a solid dosage formulation. This gum will form highly viscous dispersions, and this is a characteristic of linear gums [ 9 ]. With all these absorptive properties of high HC, SI, and WRC in pH 7.4 (small intestine) than pH 6.8 (colon), pCmG may be a good drug delivery carrier for colon-targeting preparations and a good tablet disintegrant.…”

Section: Resultsmentioning

confidence: 99%

“…Exudate gum is one of the two types of plant-based gums obtained from trees and shrubs [ 1 ], usually by breakdown of cell walls of certain plants, following injury caused by insect borers, human activities (tapping), and diseases and/or under adverse growth conditions such as drought, bushfires, or soil conditions [ 2 – 8 ]. However, the process of gummosis is suggested as a mode of protective mechanism by sealing off the site of injury against microbial infection and/or excessive loss of water after injury and, therefore, not normal physiological product of metabolism [ 9 – 11 ]. Plant gums are hydrosoluble or hydrogel complex nonstarch polysaccharide polymers which are very versatile in application.…”

Section: Introductionmentioning

confidence: 99%

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Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Kipo

Ofori-Kwakye

Kuntworbe

et al. 2023

The Scientific World Journal

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The development of a raw material into an acceptable pharmaceutical excipient involves evaluation of the physicochemical and formulation properties of the potential raw material. Results from these evaluations may serve as a guide to subsequent use of the substance. The objective of the study was to evaluate the physicochemical and microbiological properties of the stem bark gum of Cordia millenii tree in conventional release paracetamol tablets. From the physicochemical evaluations, the gum was slightly acidic and soluble in all the aqueous-based solvents, except 0.1 N HCl in which it was sparingly soluble. All the absorptive properties of the gum indicated tablet disintegrating potential for tablet formulation. The total ash of the gum was higher than that of the international standard gum arabic. Micromeritic properties of the gum indicated the need for a flow aid to improve its flowability. There were no harmful microorganisms detected in the gum. Aerobic organisms and moulds and yeast were detected within permissible limits. Tablets formulated using six different concentrations of gum dispersions as a binder were generally soft and failed the USP T80 standard of dissolution, indicating poor binding and drug releasing properties. Quality control properties of three different batches of tablets containing varying concentrations of the dry gum as a disintegrating agent were comparable to tablets containing equal concentrations of corn starch. The in vitro drug releases were similar at all-time points of drug evaluation. The gum can therefore be considered as a good disintegrant in the formulation of conventional release tablets.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Kipo

Ofori-Kwakye

Kuntworbe

et al. 2023

The Scientific World Journal

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Optimal Production of β-Galactosidase from Lactobacillus fermentum for the Synthesis of Prebiotic Galactooligosaccharides (Gos)

Mahadevaiah¹,

Basavaiah²,

Parida³

et al. 2020

J Pure Appl Microbiol

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The enzyme β-galactosidase (β-gal) has extensively used for improvement of lactose intolerance condition. Present study, was designed to assess the potential of β-gal enzyme produced by Lactobacillus fermentum, a kefir isolate, as a biocatalyst for the manufacture of prebiotic galactooligosaccharides (GOS) from lactose. The efficiency of L. fermentum to produce β-gal of 4,254 u/ml was determined by permeabilizing the cells with solvents such as sodium dodecyl sulfate (SDS) and chloroform. Different parameters contributing β-gal production including reaction time, temperature, pH, carbohydrates, and substrate concentration on L. fermentum were studied and optimum β-gal activity was found to be 6,232.13 u/ml. It was observed that different experimental parameters for pH (7.0), temperature (35°C), and carbohydrates (galactose) were statistically significant (p<0.05). L. fermentum was found to produce GOS by transgalactosylation catalysed by β-gal during lactose hydrolysis which yielded di, tri, and tetra oligosaccharides, confirmed by TLC and HPLC. The culture showed β-gal activity, suggesting biotechnological applications and a promising organism for industrial β-gal production.

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Pharmacognostic Studies and Chromatographic Analysis of the Gum of Anacardium occidentale L (Anacardiaceae)

Cited by 2 publications

References 4 publications

Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Optimal Production of β-Galactosidase from Lactobacillus fermentum for the Synthesis of Prebiotic Galactooligosaccharides (Gos)

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