Pharmacognostical and Phytochemical Evaluation of Leaves of Cissampelos pareira

Abstract

In ethanomedicinal practices the the tradicinal healers use the roots of Cissampelos pareira in the treatment of various ailments related to urinary problems, skin infections,in tumor inhibitor activity,antibacterial, antimalarial, diuretic activity and anticonvulsant activity etc. Macro-and microscopical characters, behaviour of drug on treatment with different chemical reagents, fluorescence analysis, extractive values, ash values and preliminary phytochemical tests were carried out to study the distinctive features of the drugs. Such parameters provide basis for standardisation/characterisation of genuine drug. A serious limitation encountered in the use and research of traditional medicine is the lack of standardisation and quality control of raw material forming the drug. the ultimate objective of the pharmcognostic investigation is identification of the genuine crude drug and determining the extent of adulteration/substitution, if any. Advancement in recent years in pharmacognosy, phytochemistry and physicochemical techniques can be of immense value in removing this major shortcoming of traditional medicine. These techniques can be utilised for correct botanical identification of plants. The details of organoleptic, macro-and microscopic characters, various evaluative parameters, fluorescence analysis, results of preliminary phytochemical analysis established in the present study will facilitate in identifying the g drug from any substitute or spurious samples and will also be useful in preparation of monographs on these plants.

GC-MS Analysis of Chemical Constituents of Hydroalcoholic Leaf Extract of Cissampelos Pareira and Their Anti-Diabetic Activity

“…The dried marc was further extracted with a mixture of ethanol:water (5:5) (1000 ml) using continuous extraction until a drop of solvent from the siphon tube became clear. The obtained extract was filtered, concentrated, and stored until further use [8].…”

Isolation and Elucidation of 15-Acetylguanacone from Soursop (<i>Annona muricata</i> Linn) Fruit and Molecular Docking Experiments

“…Some of the modes by which they carry out anticancer actions has been reported to include the inhibition of NADH-ubiquinone oxidoreductase (complex I) in mitochondria, inhibition of both P-glycoprotein pump (used by resistant cancer cells) and NADH oxidase (Morré et al, 1995;Gupta et al, 2011), depleting ATP (adenosine triphosphate), especially for cancer cells with high metabolic levels, leading to apoptosis. Amongst the reported acetogenin is the guanacone acetogenin, a 10-keto bis-tetrahydrofuran compound (Barrachina et al, 2007;Gallardo et al, 1998) that was initially isolated from Annona spraguei Saff.…”