Pharmacoinformatics-based identification of phytochemicals from
            <i>Solanum torvum</i>
            Swartz. fruits as potential inhibitors for MAPK14 protein

Petchimuthu, Priya; Ala, Chandu; Kunjiappan, Selvaraj; Pavadai, Parasuraman; Murugesan, Sankaranarayanan; Pandian, Sureshbabu Ram Kumar; Sundar, Krishnan

doi:10.1080/07391102.2023.2246562

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Cited by 3 publications

References 52 publications

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Solanum torvum induces ferroptosis to suppress hepatocellular carcinoma

Lai,

Weng,

Huang

et al. 2024

Journal of Ethnopharmacology

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Solanum torvum induces ferroptosis to suppress hepatocellular carcinoma

Lai,

Weng,

Huang

et al. 2024

Journal of Ethnopharmacology

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Mimosa pudica Linn. extract improves aphrodisiac performance in diabetes-induced male Wister rats

Palanichamy,

Nayak Ammunje,

Pavadai

et al. 2023

Journal of Biomolecular Structure and Dynamics

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Sorghum grain-derived Kafirin nanoparticles for effective delivery of Corosolic acid into breast cancer cells for potential treatment of breast cancer

Petchimuthu,

Kunjiappan,

Pandian

et al. 2024

Preprint

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The protein nanocarrier technology provides various benefits, including the successful delivery of loaded drugs into cancer cells. After delivery, the drug carrier is degraded and expelled from the body. In the present work, corosolic acid-encapsulated kafirin nanoparticles (CA-Kaf NPs) were successfully developed to deliver corosolic acid into MCF-7 cells effectively. Initially, kafirin protein was isolated from sorghum grains and confirmed. Then, corosolic acid was loaded into kafirin protein using a modified desolvation method, and their physicochemical properties, stability, drug release, and cytotoxic potential were investigated. The efficiency of encapsulating corosolic acid into Kaf NPs was 81.13 ± 1.27% and the loading capacity was 8.38 ± 0.51%. The CA-Kaf NPs exhibited an amorphous, spherical shape with a size range of 280–680 nm and a zeta potential of + 2 mV. CA-Kaf NPs released corosolic acid slowly and steadily in an acidic medium (pH 5.4) and are highly biocompatible in a physiological environment. CA-Kaf NPs significantly reduced the viability of MCF-7 cells after 24 h with IC50 value of 58.85 µg × mL− 1 and induced apoptosis. MCF-7 cells treated with CA-Kaf NPs, showed standard apoptotic morphological changes including contracted nuclei and damaged membrane bodies. The release of corosolic acid, from CA-Kaf NPs, leads to a significant increase in reactive oxygen species and damages the mitochondrial membrane potential integrity. These findings imply that CA-Kaf NPs, which target the delivery of corosolic acid into MCF-7 cells and facilitate endocytosis, could have a significant therapeutic potential for breast cancer.

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Pharmacoinformatics-based identification of phytochemicals from Solanum torvum Swartz. fruits as potential inhibitors for MAPK14 protein

Cited by 3 publications

References 52 publications

Solanum torvum induces ferroptosis to suppress hepatocellular carcinoma

Solanum torvum induces ferroptosis to suppress hepatocellular carcinoma

Mimosa pudica Linn. extract improves aphrodisiac performance in diabetes-induced male Wister rats

Sorghum grain-derived Kafirin nanoparticles for effective delivery of Corosolic acid into breast cancer cells for potential treatment of breast cancer

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