Pharmacokinetic analysis of ductal carcinoma in situ of the breast using dynamic MR mammography

Oshida, Keiko; Nagashima, Takeshi; Ueda, Takeshi; Yagata, Hiroshi; Tanabe, Naoto; Nakano, Soichiro; Nikaidou, Takashi; Fukatsu, Hiroshi; Hashimoto, Hideyuki; Miyazaki, Masaru

doi:10.1016/j.clinimag.2005.09.004

Cited by 4 publications

(4 citation statements)

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“…Early rim enhancement correlates well with a high ratio of peripheral-to-central microvessel density and peripheral vascular endothelial growth factor (VEGF) expression. [51][52][53][54][55] Quantitative DCE-MRI measurements could be used as a marker to monitor tumor antiangiogenic therapy. [56][57][58] ACR BI-RADS MRI Lexicon ACR BI-RADS MRI lexicon includes 2 major categories of descriptors, morphology and enhancement kinetics.…”

Section: Breast Tumor Angiogenesis and Enhancementmentioning

confidence: 99%

Significance of breast lesion descriptors in the ACR BI‐RADS MRI lexicon

Agrawal

Nalcioğlu

et al. 2009

Cancer

108

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In recent years, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has altered the clinical management for women with breast cancer. In March 2007, the American Cancer Society (ACS) issued a new guideline recommending annual MRI screening for high-risk women. This guideline is expected to substantially increase the number of women each year who receive breast MRI. The diagnosis of breast MRI involves the description of morphological and enhancement kinetics features. To standardize the communication language, the Breast Imaging Reporting and Data System (BI-RADS) MRI lexicon was developed by the American College of Radiology (ACR). In this article, the authors will review various appearances of breast lesions on MRI by using the standardized terms of the ACR BI-RADS MRI lexicon. The purpose is to familiarize all medical professionals with the breast MRI lexicon because the use of this imaging modality is rapidly growing in the field of breast disease. By using this common language, a comprehensive analysis of both morphological and kinetic features used in image interpretation will help radiologists and other clinicians to communicate more clearly and consistently. This may, in turn, help physicians and patients to jointly select an appropriate management protocol for each patient's clinical situation. In March 2007, the American Cancer Society (ACS) issued a new guideline recommending annual screening for high-risk women using breast magnetic resonance imaging (MRI). MRI is recommended as an adjunct to mammography for women with a lifetime risk of 20%-25% or greater, including women with a strong family history of breast or ovarian cancer and women who had been treated for Hodgkin disease. 1 For women with a 15% to 20% lifetime risk, based on the analysis of multiple risk factors such as a personal history of breast cancer, carcinoma in situ, atypical hyperplasia, and extremely dense breasts on mammography, the ACS suggested that the screening decisions should be made on a case-by-case basis. 2 Breast MRI can alter the clinical management for a sizable fraction of women with early stage breast cancer and help in determining the optimal local treatment. [3][4][5][6] Kuhl et al concluded that MRI screening of women with a history of familial or hereditary breast cancer can achieve a significantly higher sensitivity

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Section: Breast Tumor Angiogenesis and Enhancementmentioning

confidence: 99%

Significance of breast lesion descriptors in the ACR BI‐RADS MRI lexicon

Agrawal

Nalcioğlu

et al. 2009

Cancer

108

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“…However, the association between contrast-enhanced magnetic resonance imaging (MRI) and MVD has been investigated and has resulted in mixed reports. [20][21][22] Several researchers 23,24 reported that MRI gadolinium enhancement of breast lesions was not an accurate predictor of MVD. One explanation is that MRI enhancement of breast lesions is not only related to vessel density but probably also related to hemodynamic and capillary permeability and the size of the extracellular space, whereas ultrasonographic contrast agents are true intravascular agents, unlike the diffusible agents commonly used in MRI or computed tomography.…”

Section: Assessment Of Angiogenesis In Breast Lesionsmentioning

confidence: 99%

Correlation of Real-time Gray Scale Contrast-Enhanced Ultrasonography With Microvessel Density and Vascular Endothelial Growth Factor Expression for Assessment of Angiogenesis in Breast Lesions

Fang

et al. 2008

Journal of Ultrasound in Medicine

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“…This causes characteristic contrast enhancement kinetics (plateau and washout phenomenon) (18,19). Angiogenesis-induced vessel sprouting and alteration of vessel wall permeability are thought to lead to the strong and fast contrast enhancement observed in dynamic MRI study of invasive breast cancers (20).…”

Section: Discussionmentioning

confidence: 99%

MRI Criteria for Predicting Invasive Lesions in Biopsy-Proven Ductal Carcinoma in Situ

이

박

고

et al. 2019

J Korean Soc Radiol

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Purpose To evaluate the criteria for predicting invasive lesions with preoperative breast MRI in ductal carcinoma in situ (DCIS) histopathologically diagnosed with biopsy. Materials and MethodsWe retrospectively analyzed the preoperative MRI findings of 80 percutaneous biopsy-proven DCIS. The morphological type, enhancement distribution and kinetics, and extent of the lesions were analyzed. We compared the results of pure DCIS and DCIS with invasive lesions. We evaluated the MRI criteria for predicting DCIS with invasive lesions and assessed its diagnostic performance. ResultsOf the 80 DCIS lesions analyzed, 27 contained co-existing invasive lesions and 49 were pure DCIS. No residual lesions after biopsy were seen in 4 cases. DCIS with invasive lesions showed washout kinetics more frequently and to a larger extent than did pure DCIS (p = 0.030 and p = 0.048, respectively). Using enhancement kinetics and the lesion cut-off value of 4 cm yielded the highest diagnostic performance, with 92.6% sensitivity and 93.8% negative predictive value for predicting invasive lesions. ConclusionWashout kinetics and the lesion extent of at least 4 cm are useful criteria for the prediction of co-existing invasive lesions in patients with DCIS diagnosed with biopsy.

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Pharmacokinetic analysis of ductal carcinoma in situ of the breast using dynamic MR mammography

Cited by 4 publications

References 0 publications

Significance of breast lesion descriptors in the ACR BI‐RADS MRI lexicon

Significance of breast lesion descriptors in the ACR BI‐RADS MRI lexicon

Correlation of Real-time Gray Scale Contrast-Enhanced Ultrasonography With Microvessel Density and Vascular Endothelial Growth Factor Expression for Assessment of Angiogenesis in Breast Lesions

MRI Criteria for Predicting Invasive Lesions in Biopsy-Proven Ductal Carcinoma in Situ

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