Pharmacokinetic and pharmacodynamic characteristics of trazodone in the elderly.

Bayer, Antony James; Pathy, M. S.; Ankier, S. I.

doi:10.1111/j.1365-2125.1983.tb02180.x

Cited by 60 publications

(28 citation statements)

References 16 publications

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“…Cma,c showed no significant difference between mean values obtained with and without ethanol for either treatment (Table 4) Bayer et al, 1983;Jorgensen & Staer, 1976). Ethanol administration did not modify these except in the case of tmax for trazodone which was prolonged perhaps due to an ethanol-induced delay in gastric emptying.…”

Section: Total Choice Reaction Time (Crt; Figure 2)mentioning

confidence: 88%

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An evaluation of possible interactions between ethanol and trazodone or amitriptyline.

Warrington¹,

Ankier²,

Turner³

1984

Brit J Clinical Pharma

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The pharmacodynamic effects of single doses of trazodone (100 mg), amitriptyline (50 mg) or placebo either alone or with ethanol (0.5 ml/kg) were investigated in six healthy volunteers in a double‐blind crossover study. Plasma concentrations of the drugs and ethanol were also measured. Pharmacodynamic tests were critical flicker fusion frequency threshold (CFF), choice reaction time (CRT), manual dexterity, a digit span test and visual analogue scales. Blood ethanol concentrations were not influenced by the co‐administration of either antidepressant. tmax for trazodone was prolonged by ethanol but the other pharmacokinetic parameters for trazodone and amitriptyline were not influenced by ethanol. Trazodone and amitriptyline caused the expected profound depressant effects on CFF, CRT, manual dexterity and on the rating scales for drowsiness, ‘clear‐headedness’, aggression and disinhibition. Ethanol alone impaired manual dexterity, increased drowsiness, reduced ‘clear headedness’ and also tended to reduce feelings of aggression. In combination with either trazodone or amitriptyline, ethanol caused little additional effect except in the case of manual dexterity which was further impaired. This result may reflect the profound effects of the antidepressants alone and does not suggest that it is safe for patients receiving antidepressant medication to take ethanolic drinks.

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Section: Total Choice Reaction Time (Crt; Figure 2)mentioning

confidence: 88%

“…Trazodone is an antidepressant agent with a chemical structure unrelated to existing psychomotor drugs (Al-Yassiri et al, 1981;Brogden et al, 1981;Ayd & Settle, 1982;Georgotas et al, 1982;Rawls, 1982) which is sedative and impairs critical flicker fusion threshold in young and elderly volunteers (Bayer et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

An evaluation of possible interactions between ethanol and trazodone or amitriptyline.

Warrington¹,

Ankier²,

Turner³

1984

Brit J Clinical Pharma

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“…The half-life of trazodone in the young individual is approx imately 6.4 h, compared with 11.6 in older individuals (24 and 69.5 years of age, respec tively). This is reflected in the decreased clearance rate in the older group as com pared with the younger group (6.3 vs. 10.8) [54] . These differences in half-life are of little clinical significance, since even in the geriat ric population it would only take 2 days to reach a steady state at a given dose.…”

Section: Pharmacokinetics and Dynamicsmentioning

confidence: 98%

Geriatric Depression and Treatment with Trazodone

Gerner

1987

Psychopathology

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With the growing number of Americans over the age of 65 years, the high incidence of geriatric depression has become a major concern in the United States. Age-related circumstances – increased incidence of illness, bereavement, financial difficulties, and institutionalization – may contribute to an increased rate of depression in this age group. The signs and symptoms of depression in elderly patients are similar to those seen in younger individuals; therefore, standard Diagnostic and Statistic Manual III (DSM-III) criteria are reliable for making a diagnosis. However, symptoms such as insomnia, obsessional thought, and hypochondriasis may be relatively increased in the elderly patient; and the diagnosis of geriatric depression can be complicated by signs and symptoms of depression that may overlap with those of dementia. In the geriatric group, the mainstay of pharmacotherapy has been the reuptake antidepressant agents. Choice of antidepressant therapy is largely based on the side-effect profile. Thus, the fewer and less severe side effects associated with trazodone make it a suitable drug choice in these patients. Trazodone has been shown to demonstrate comparable efficacy to the other reuptake and monoamine oxidase inhibitors, but has the advantages of a low cardiovascular-risk profile, extremely low suicide toxicity, absence of anticholinergic side effects, and minimal effects on cognition.

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“…The pharmacokinetic and pharmacody namic characteristics of trazodone have been studied in the normal elderly popula tion [35]. The maximal plasma concentra tion after a single, 100-mg dose was similar in both elderly and young volunteers, but in the elderly subjects, the terminal phase halflife was significantly prolonged and the area under the plasma concentration-time curve was significantly larger.…”

Section: Use In the Elderly Patientmentioning

confidence: 99%

Recent Experience with Trazodone

Lader¹

1987

Psychopathology

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Trazodone is an atypical antidepressant with additional anxiolytic effects. Recent European experience with trazodone is reviewed with respect to antidepressant efficacy, side effects (particularly anticholinergic), anxiolytic actions, cardiotoxicity, overdosage, and use in the elderly. From the data presented in this paper it is concluded that trazodone is effective both as an antidepressant and as an anxiolytic agent, with few side effects and low cardiotoxicity. It is safer than tricyclic antidepressant agents in overdosage and better tolerated in the elderly patient.

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Pharmacokinetic and pharmacodynamic characteristics of trazodone in the elderly.

Cited by 60 publications

References 16 publications

An evaluation of possible interactions between ethanol and trazodone or amitriptyline.

An evaluation of possible interactions between ethanol and trazodone or amitriptyline.

Geriatric Depression and Treatment with Trazodone

Recent Experience with Trazodone

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