The objective was to determine the magnitude of the EVER206 free-plasma area under the concentration time curve (
f
AUC)/MIC target associated with bacteriostasis and 1-log
10
kill against clinically relevant Gram-negative bacteria in the murine thigh model. Twenty-seven clinical isolates (
Pseudomonas aeruginosa
,
n
= 10;
Escherichia coli
, n
= 9;
Klebsiella pneumoniae
,
n
= 5;
Enterobacter cloacae
,
n
= 2; and
Klebsiella aerogenes
,
n
= 1) were tested.