1997
DOI: 10.1016/s0378-4347(97)00394-0
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Pharmacokinetic behaviour of R-(+)- and S-(−)-amlodipine after single enantiomer administration

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Cited by 54 publications
(29 citation statements)
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“…Amlodipine plasma and serum levels have been detected by different methods such as thinlayer chromatography (LOQ = 2.0 ng/ml) [1], liquid chromatography with amperometric detection (LOQ = 0.2 ng/ml; RT = 8.5 min) [3], and liquid chromatography with ultraviolet detection (LOQ = 0.2 ng/ml; RT>40 min) [4]. Other methods such as capillary electrophoresis (LOQ = 5.0 ng/ml; RT = 9.8 min) [5], and gas chromatography (LOQ = 2.5 ng/ml; RT>9.0 min) [6] were also used to detect amlodipine plasma levels.…”
Section: Resultsmentioning
confidence: 99%
“…Amlodipine plasma and serum levels have been detected by different methods such as thinlayer chromatography (LOQ = 2.0 ng/ml) [1], liquid chromatography with amperometric detection (LOQ = 0.2 ng/ml; RT = 8.5 min) [3], and liquid chromatography with ultraviolet detection (LOQ = 0.2 ng/ml; RT>40 min) [4]. Other methods such as capillary electrophoresis (LOQ = 5.0 ng/ml; RT = 9.8 min) [5], and gas chromatography (LOQ = 2.5 ng/ml; RT>9.0 min) [6] were also used to detect amlodipine plasma levels.…”
Section: Resultsmentioning
confidence: 99%
“…The following morning, subjects were given a single oral dose of 10-mg racemic amlodipine (Norvasc, Pfizer Pharmaceutical, Seoul, Korea). Blood samples were collected immediately prior to drug administration (baseline) and then at 1,2,3,4,5,6,7,8,9,10,12,24,48,72,96,120,144, and 168 h after drug administration. Blood samples were collected in heparinized tubes (Vacutainer; Becton Dickinson, Franklin Lakes, NJ) after discarding 1 ml of blood.…”
Section: Subjects and Study Designmentioning
confidence: 99%
“…5,6 Several studies revealed that the pharmacokinetics of amlodipine in humans is stereoselective. 4,7,8 The CYP3A subfamily is estimated to participate in the biotransformation of 50% of drugs known to undergo oxidative metabolism. 9 Four members of the CYP3A subfamily have been described in humans: CYP3A4, CYP3A5, CYP3A7, and CYP3A43.…”
Section: Introductionmentioning
confidence: 99%
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“…7 The drug displays an oral bioavailability of 50-80% with peak plasma concentrations at about 6-8 h. Amlodipine is extensively metabolized in the liver and slowly cleared with a terminal half live of 40-50 h. 4,8,9 After administration of the enantiomers of amlodipine as well as racemic amlodipine to healthy male volunteers, comparable pharmacokinetic parameters were reported for the amlodipine enantiomers but somewhat higher plasma concentrations were observed for the (S)-enantiomer. 10 In contrast, higher plasma concentrations of (R)-amlodipine than its (S)-enantiomer were reported in elderly hypertensive patients.…”
Section: Introductionmentioning
confidence: 96%