Pharmacokinetic change of nanoparticulate formulation “Lactosome” on multiple administrations

Hara, Eri; Makino, Akihiro; Kurihara, Kensuke; Yamamoto, Fujio; Ozeki, Eiichi; Kimura, Shunsaku

doi:10.1016/j.intimp.2012.07.011

Cited by 45 publications

(64 citation statements)

References 28 publications

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“…[90,96] 30 ] were rapidly captured by the liver upon second administration [97] and cleared from the bloodstream, whereas the micelles to that of at the first administration. [90] This has been attributed to the significantly reduced interaction of the micelles with densely grafted polysarcosine corona with the B lymphocyte receptors and hence the suppression of antibody production.…”

Section: Immunogenicitymentioning

confidence: 99%

“…It was also found that the polymeric micelles are T cell-independent antigen that can trigger antigen production without the help of T cells [98] and the polysarcosine was found to be the epitope from the competitive inhibition assay (ELISA). [97] In spite of these reports on polysarcosine, the immunogenicity of other polypeptoids with different N-substituent structures or compositions are unknown. As a result, one should be cautioned about making generalization about the immunogenicity of polypeptoid polymers.…”

Section: Immunogenicitymentioning

confidence: 99%

“…For example, investigation of polypeptoid-based drug delivery carriers, [90,96,97] gene delivery carriers, [78] and 3D culture/tissue engineering scaffolds has started to emerge. [87] Demonstration of their unique properties and capabilities that are unrivaled by other nonpolypeptoid-based systems will be critical in moving polypeptoids to the forefront of biomaterials applications.…”

Section: Materials Applicationsmentioning

confidence: 99%

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Polypeptoid polymers: Synthesis, characterization, and properties

et al. 2017

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Polypeptoids, a class of peptidomimetic polymers, have emerged at the forefront of macromolecular and supramolecular science and engineering as the technological relevance of these polymers continues to be demonstrated. The chemical and structural diversity of polypeptoids have enabled access to and adjustment of a variety of physicochemical and biological properties (eg, solubility, charge characteristics, chain conformation, HLB, thermal processability, degradability, cytotoxicity and immunogenicity). These attributes have made this synthetic polymer platform a potential candidate for various biomedical and biotechnological applications. This review will provide an overview of recent development in synthetic methods to access polypeptoid polymers with well-defined structures and highlight some of the fundamental physicochemical and biological properties of polypeptoids that are pertinent to the future development of functional materials based on polypeptoids. | I N TR ODU C TI ONPolypeptoids composed of N-substituted polyglycine backbones are structural mimics of polypeptides ( Figure 1). Because of N-substitution, polypeptoids lack stereogenic centers and hydrogen bonding interactions along the main chains, in sharp contrast to polypeptides.As a result, the global conformations of polypeptoids are strongly dependent on the N-substituent structures, giving rise to random coils or well-defined secondary structures [eg, polyproline I (PPI) helix [1][2][3][4][5][6] and R-sheets] [7][8][9][10][11][12] that are reminiscent of those of polypeptides. The polypeptoid backbone containing tertiary amide linkages is highly polar and hydrophilic. The physicochemical properties of polypeptoids can be tailored by the N-substituent structures, enabling control over the hydrophilicity and lipophilicity balance (HLB), charge characteristics, [13,14] backbone conformation, [1][2][3][4][5][6][7][8][9][10][11][12] solubility, [15][16][17][18][19][20] thermal and crystallization properties of the polypeptoids. [21][22][23][24] Without extensive hydrogen bonding, polypeptoids are thermally processable similar to conventional thermoplastics, [20][21][22][23][24] whereas polypeptides undergo thermal degradation before they can be melt-processed due to the extensive hydrogen bonding interactions. While polypeptoids exhibited enhanced proteolytic stability relative to peptides, [25,26] they can be oxidatively degraded under conditions that mimic tissue inflammation, [27] suggesting their potential in vivo uses as biodegradable materials.Recent advances in the controlled polymerization methods have enabled access to a suite of structurally well-defined polypeptoids with various N-substituent structures and molecular architectures, setting the stage for the future development of polypeptoid materials for various targeted applications. Several review articles on the synthesis, properties, and application of polypeptoids for biomedical or nonbiomedical uses have been published in recent years. [28][29][30][31][32] As a result, this...

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Section: Immunogenicitymentioning

confidence: 99%

Section: Immunogenicitymentioning

confidence: 99%

Section: Materials Applicationsmentioning

confidence: 99%

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Polypeptoid polymers: Synthesis, characterization, and properties

et al. 2017

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“…In most cases with a very limited number of exceptions, [21][22][23] PEG is used in the outer shell-forming polymer block for polymeric micelle carrier systems. In this section (Table 1), we explain the reasons for this very common use of PEG.…”

Section: Why Is Peg Most Commonly Used As the Outer Shell Of Polymerimentioning

confidence: 99%

Polymeric Micelles Possessing Polyethyleneglycol as Outer Shell and Their Unique Behaviors in Accelerated Blood Clearance Phenomenon

Shiraishi

Yokoyama

2013

Biological & Pharmaceutical Bulletin

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Polymeric micelles are assemblies of synthetic polymers and have been studied and developed as drug carriers for targeting. Polymeric micelles are composed of the inner core and the outer shell, and typically form from AB-type block copolymers in which two polymer blocks are connected in a tandem form. Polyethyleneglycol (PEG) has been most commonly used as one polymer block composing the outer shell. This review describes the reasons that PEG is used for the outer shell of the polymeric micelle carrier systems. On the other hand, accelerated blood clearance (ABC) phenomenon is a well-known immunological response of PEG-coated liposomes. Since the ABC phenomenon greatly influences targeting functions of carrier systems, elaborative studies on polymeric micelles' ABC phenomenon have been done, and revealed different behaviors of the polymeric micelle systems from those of PEG-coated liposomes. These studies indicate that polymeric micelle systems are highly feasible tools for contrast agent targeting as well as theranostics.

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“…[36][37][38] For example, polymeric micelles prepared from poly(Sar) 64 -b-poly(L-lactic acid) 30 induced the production of anti-poly(sarcosine) IgM and IgG with a long memory. The amounts of antipoly(sarcosine) IgM produced by the current vesicles were analysed by ELISA using Lactosome as the positive control (Fig.…”

mentioning

confidence: 99%