Pharmacokinetic characteristics of azithromycin in freshwater crocodiles (Crocodylus siamensis) after intramuscular administration at three different dosages

Abstract

9a-position in the lactone ring of azalide. This structural change provides better stability and tissue distribution than erythromycin (Coke et al., 2003;Girard et al., 1987). It is a highly lipophilic drug that can accumulate in phagocytes, increasing the drug penetration to pyogenic infection sites (Coke et al., 2003;Leclere et al., 2012). AZM blocks bacterial protein synthesis by binding the 50s ribosomal subunit, resulting in incomplete peptide chains. It has either bactericidal or bacteriostatic action, depending on the plasma concentration (Islam et al., 2012). It has broad spectrum in vitro activity against bacterial pathogens of both Gram-positive and Gram-negative bacteria, such as Staphylococcus