2020
DOI: 10.1016/j.jpba.2020.113643
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Pharmacokinetic comparative study of GAS with different concentration of tetramethylpyrazine and ferulic acid on liver–yang hyperactivity migraine model by blood–brain microdialysis method

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Cited by 9 publications
(3 citation statements)
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“…Gastrodia elata 's clinical application and its treatment in cognition-related diseases have been established for a long time. Although the ancients did not have modern diversified ways of drug analysis, through long-term practice, we have found that Gastrodia elata combined with other drugs can increase the utilization rate in the nervous system of the active components of Gastrodia elata , resulting in better efficacy [ 108 ]. In modern times, the ancient prescription is packaged by modern ways, such as Antongshutong capsule.…”
Section: Resultsmentioning
confidence: 99%
“…Gastrodia elata 's clinical application and its treatment in cognition-related diseases have been established for a long time. Although the ancients did not have modern diversified ways of drug analysis, through long-term practice, we have found that Gastrodia elata combined with other drugs can increase the utilization rate in the nervous system of the active components of Gastrodia elata , resulting in better efficacy [ 108 ]. In modern times, the ancient prescription is packaged by modern ways, such as Antongshutong capsule.…”
Section: Resultsmentioning
confidence: 99%
“…Its BBB permeation index is −2.29 (less than −0.3 is considered unable to permeate the BBB). After administration, the amount of gastrodin in the brain is very small, and it is rapidly degraded and metabolised [ 31 ]. In the past, it was thought that gastrodin may act by degrading into gastrodin aglycones, which can pass through the BBB more easily; however, this hypothesis has since been overturned and gastrodin has been determined to act alone [ 32 ].…”
Section: Discussionmentioning
confidence: 99%
“…It shows an ideal therapeutic effect on cardiovascular and cerebrovascular diseases, and is also used as a preventive medicine to supply the vitamins necessary to maintain tness [3] . In clinical practice, Ligusticum chuanxiong is widely used to treat thromboembolism heart diseases [4] , headache [5,6] , wind-damp [7] . Recent studies have found that the active metabolites of Ligusticum chuanxiong including ligustrazine [8] , ferulic acid [9] , ligustilide [10] , polysaccharide and the others [11] .…”
Section: Introductionmentioning
confidence: 99%