Pharmacokinetic comparisons of five ephedrine alkaloids following oral administration of four different Mahuang–Guizhi herb-pair aqueous extracts ratios in rats

Wei, Ping; Huo, Huiling; Ma, Qing; Li, Han-cheng; Xing, Xuefeng; Tan, Xiaomei; Jia-bo, Luo

doi:10.1016/j.jep.2014.05.065

Cited by 33 publications

(19 citation statements)

References 9 publications

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“…Until now, manu studies have focused on the herb‐pair of CR using modern analytical technologies, such as LC–MS. For instance, Wei et al () performed a pharmacokinetic study of Mahuang–Guizhi pair in rats and simultaneously determined five ephedrine alkaloids using a UPLC–MS/MS approach. Moreover, Wang et al () developed an HPLC–MS approach to determine one phenolic acid and two flavonoids in Guizhi–Gancao pair and applied it to a pharmacokinetic study.…”

Section: Introductionmentioning

confidence: 99%

A sensitive UPLC–MS/MS method for simultaneous determination of polyphenols in rat plasma: Application to a pharmacokinetic study of dispensing granules and standard decoction of Cinnamomum cassia twigs

Tao

Yan

et al. 2019

Biomedical Chromatography

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This study established a rapid and reliable approach using liquid chromatography–tandem mass spectrometry for the simultaneous determination of cinnamic acid, vanillic acid and protocatechuic acid in rat plasma. This is the first report on a comparative pharmacokinetic study of dispensing granules and standard decoction of Cinnamomum cassia twigs in rats. After liquid–liquid extraction by ethyl acetate, the plasma samples were subjected to LC–MS/MS for multiple reaction monitoring. The standard curves showed good linear regression (r2 > 0.9991) in the range of 10.0–16000 ng/mL. The intra‐ and inter‐day accuracy and precision were found to be within 15% of the nominal concentration. The recoveries of the three phenolics ranged from 88.7 to 105.7%. Finally, this approach was successfully applied to pharmacokinetic analysis of the three phenolics after oral administration of standard decoction and dispensing granules of C. cassia twigs in rats. Although the values of AUC0–t of vanillic acid and protocatechuic acid in standard decoction group were larger than those of the dispensing granule group, no significant difference was observed for the two groups. Of note, the elimination rates of vanillic acid were slower in the standard decoction group than the dispensing granule group.

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Section: Introductionmentioning

confidence: 99%

A sensitive UPLC–MS/MS method for simultaneous determination of polyphenols in rat plasma: Application to a pharmacokinetic study of dispensing granules and standard decoction of Cinnamomum cassia twigs

Tao

Yan

et al. 2019

Biomedical Chromatography

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“…The major bioactive component of Rhizoma Zingiberis is Compound D, (E)-4-(3′, 4′-dimethoxyphenyl) but-3-en-1-ol, which has a strong smooth muscle relaxant, and has antihistamine and anti-inflammatory actions [74]. Ramulus Cinnamomi (Cassia twig), used to improve pharmacological effects and reduce toxicity [75]. Ginseng can inhibit H. pylori induced gastric inflammation by suppressing induction of inflammatory mediators, myeloperoxidase activity, and lipid peroxide level in H. pylori-infected gastric mucosa [76].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Jianzhong decoction in treating peptic ulcers: a meta-analysis of 58 randomised controlled trials with 5192 patients

Sun

Zhang

Chen³

2017

BMC Complement Altern Med

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BackgroundJianzhong decoction is widely used to treat peptic ulcers; however, due to lack of systematic evaluations, its clinical efficacy remains controversial. We performed meta-analysis to evaluate the efficacy and safety of Jianzhong decoction in treating peptic ulcers.MethodsStudies were systematically retrieved from PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, Wanfang Database, Chongqing VIP, China Biology Medicine disc (CBMdisc), and references cited in related studies/reviews. Extracted data included the total effective rate, helicobacter pylori eradication rates, recurrence rate, and adverse reaction rate. Fifty-eight randomised controlled trials involving 5192 patients were included in the final analysis.ResultsResults showed that Jianzhong decoction therapy was more effective than conventional Western medicine therapy (total effective rate, odds ratio [OR] = 4.29, 95% confidence interval [CI]: 3.51–5.23, P = 0.000; helicobacter pylori eradication rates, OR =2.10, 95% CI: 1.69–2.61, P = 0.000; recurrence rate, OR =0.23, 95% CI: 0.18–0.29, P = 0.000; and adverse reaction rate, OR =0.20, 95% CI: 0.12–0.33, P = 0.000).ConclusionsJianzhong decoction increased the total effective rate and helicobacter pylori eradication rate, and lowered the recurrence and adverse reaction rates. The results of this study can be used as a guide for clinical treatment of peptic ulcers.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-017-1723-2) contains supplementary material, which is available to authorized users.

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“…The rotarod test was performed as previously reported. 19) The day prior to the test, the mice were familiarized with the rotarod test by placing them on a rotating rod (28 rpm) for 5 min; this training was repeated 6 times every hour. On the day of the rotarod test, the mice were trained again; those that fell off the rotating rod were excluded from this experiment.…”

Section: Methodsmentioning

confidence: 99%

Analgesic Effects of Ephedra Herb Extract, Ephedrine Alkaloids–Free Ephedra Herb Extract, Ephedrine, and Pseudoephedrine on Formalin-Induced Pain

Nakamori

Takahashi

Hyuga

et al. 2019

Biological & Pharmaceutical Bulletin

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The analgesic effect of Ephedra Herb (EH) is believed to be derived from the anti-inflammatory action of pseudoephedrine (Pse). We recently reported that ephedrine alkaloids-free EH extract (EFE) attenuates formalin-induced pain to the same level as that achieved by EH extract (EHE), which suggests that the analgesic effect of EH may not be due to ephedrine alkaloids (EAs). To examine the contribution of EAs to the analgesic effect of EH, mice were injected with formalin to induce a biphasic pain reaction (first phase, 0-5 min; second phase, 10-45 min) at various time points after oral administration of the following test drugs: ephedrine (Eph), Pse, "authentic" EHE from Tsumura & Co. (EHE-Ts), EFE, and EHE that was used as the source of EFE (EHE-To). Biphasic pain was suppressed at 30 min after administration of Eph, EHE-Ts, and EHE-To. At 6 h after administration of EFE, EHE-To, and Pse-and at 4 to 6 h after administration of EHE-Ts-only second-phase pain was suppressed; however, the effect of Pse at 6 h was not significant. These results suggested that EHE has a biphasic analgesic effect against biphasic formalin-induced pain: in the first phase of analgesia (30 min after administration), biphasic pain is suppressed by Eph; in the second phase of analgesia (4-6 h after administration), second-phase pain is alleviated by constituents other than EAs, although Pse may partially contribute to the relief of second-phase pain.

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Pharmacokinetic comparisons of five ephedrine alkaloids following oral administration of four different Mahuang–Guizhi herb-pair aqueous extracts ratios in rats

Cited by 33 publications

References 9 publications

A sensitive UPLC–MS/MS method for simultaneous determination of polyphenols in rat plasma: Application to a pharmacokinetic study of dispensing granules and standard decoction of Cinnamomum cassia twigs

A sensitive UPLC–MS/MS method for simultaneous determination of polyphenols in rat plasma: Application to a pharmacokinetic study of dispensing granules and standard decoction of Cinnamomum cassia twigs

Efficacy and safety of Jianzhong decoction in treating peptic ulcers: a meta-analysis of 58 randomised controlled trials with 5192 patients

Analgesic Effects of Ephedra Herb Extract, Ephedrine Alkaloids–Free Ephedra Herb Extract, Ephedrine, and Pseudoephedrine on Formalin-Induced Pain

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