Pharmacokinetic comparisons of hydroxysafflower yellow A in normal and blood stasis syndrome rats

Taoren–Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation

“…The blood stasis model was built during the time interval that two injections of adrenaline hydrochloride (Adr) were given into rats placed in ice-cold water. These data of the hemorheological and blood coagulation parameters suggested that injection of Adr combined with exposure to ice-cold water might induce blood stasis, resulting in hemorheological abnormalities (Chen, 2006;Lu et al, 2008;Tian et al, 2010).…”

Pharmacokinetic comparisons of puerarin, daidzin and the glucuronide metabolite of puerarin after administration of total flavonoid from Gegen alone and total flavonoid from Gegen combined with total saponin from Sanqi in rats under different physiological states

“…From this it can be inferred that blood stasis syndrome could have an effect on the pharmacokinetic behavior of puerarin and daidzin and the metabolism of puerarin. Tian et al [19] reported that blood stasis syndrome appears to have an effect on the enzymes in rat liver, especially the cytochrome P450s (CYP), which are considered as important drug-metabolizing enzymes. For most isoflavonoids, the liver is the primary site of metabolism [2].…”

“…The pharmacokinetic behavior of drugs in blood can be affected by disease conditions [19]. However, there is no published information about the simultaneous determination of puerarin-7-O-glucuronide, puerarin and daidzin (structures shown in Fig.…”

Enhanced absorption of hydroxysafflor yellow A using a self-double-emulsifying drug delivery system: in vitro and in vivo studies

“…Chromatographic conditions were performed according to the literature, 13 with some modifications. Samples were determined using an Agilent 1200 HPLC system with ZORBAX SB-C18 (4.6 mm × 250 mm, 5 µm) (Agilent, Santa Clara, CA).…”