Pharmacokinetic considerations for angiogenesis inhibitors used to treat hepatocellular carcinoma: an overview

Borriello, Raffaele; Cerrito, Lucia; Gasbarrini, Antonio; Ponziani, Francesca Romana

doi:10.1080/17425255.2023.2272598

Cited by 4 publications

(1 citation statement)

References 108 publications

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“…As mentioned above, angiogenesis is one of the most important processes for tumour development. Therefore, antiangiogenic therapy (AAT) has attracted attention, and many drugs are being studied [ 154 – 156 ]. Four main strategies are considered to develop antiangiogenic agents: inhibiting endogenous factors promoting angiogenesis, identifying and applying natural angiogenesis inhibitors, inhibiting the molecules that promote the invasion of the surrounding tissue through tumour blood vessels, and incapacitating actively proliferating endothelial cells [ 53 ].…”

Section: Introductionmentioning

confidence: 99%

Research progress of exosomes in the angiogenesis of digestive system tumour

Liu,

Wu,

Sang

et al. 2024

Discov Onc

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Malignant tumours of the digestive system cover a wide range of diseases that affect the health of people to a large extent. Angiogenesis is indispensable in the development, and metastasis of tumours, mainly in two ways: occupation or formation. Vessels can provide nutrients, oxygen, and growth factors for tumours to encourage growth and metastasis, so cancer progression depends on simultaneous angiogenesis. Recently, exosomes have been proven to participate in the angiogenesis of tumours. They influence angiogenesis by binding to tyrosine kinase receptors (VEGFR)-1, VEGFR-2, and VEGFR-3 with different affinities, regulating Yap-VEGF pathway, Akt pathway or other signaling pathway. Additionally, exosomes are potential therapeutic vectors that can deliver many types of cargoes to different cells. In this review, we summarize the roles of exosomes in the angiogenesis of digestive system tumours and highlight the clinical application prospects, directly used as targers or delivery vehicles, in antiangiogenic therapy.

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Section: Introductionmentioning

confidence: 99%