1995
DOI: 10.2165/00003088-199528010-00005
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Pharmacokinetic Considerations in Gastrointestinal Motor Disorders

Abstract: Although it has been recognised that alterations in gastrointestinal motility, whether induced by physiological or pathological processes, have significant effects on the pharmacokinetics of orally administered drugs, this subject has received inappropriately little attention. Studies relating to this topic have focused on healthy volunteers and animals and have largely been confined to the effects of single drug doses. There is limited information about the effects of disease on pharmacokinetics under steady-… Show more

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Cited by 49 publications
(35 citation statements)
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“…Delayed gastric emptying in patients with gastroparesis alters glucose absorption and the mismatch between glucose absorption and insulin action results in wide excursions in blood glucose concentrations with MDI regimens [7]. In addition, patients with severe symptomatic gastroparesis are unable to have regular meals and frequently omit their insulin in an attempt to avoid the risk of hypoglycaemia.…”
Section: Discussionmentioning
confidence: 99%
“…Delayed gastric emptying in patients with gastroparesis alters glucose absorption and the mismatch between glucose absorption and insulin action results in wide excursions in blood glucose concentrations with MDI regimens [7]. In addition, patients with severe symptomatic gastroparesis are unable to have regular meals and frequently omit their insulin in an attempt to avoid the risk of hypoglycaemia.…”
Section: Discussionmentioning
confidence: 99%
“…The delay of gastric emptying by ingested foods was also reported to cause the delay of the absorption of several drugs, including theophylline in human. 52,53) The analysis using GITA Model and gamma scintigraphic technique made it possible to estimate the variable absorption kinetics regulated by the GI transit with a huge variability. The plasma concentration-time profile of theophylline after oral administration in human volunteers was predicted using the individual GI transit data monitored by a gamma scintigraphic technique.…”
mentioning
confidence: 99%
“…2 For some medicines, this can be associated with a withdrawal or discontinuation syndrome (see Table), 3,4 which is predictable and potentially avoidable. This is a particular concern with shorter acting drugs in a controlledrelease formulation (which depends on normal gut transit time) when the decrease in plasma concentration reduces the patient's functional status (e.g.…”
Section: Controlled-release Formulationsmentioning
confidence: 99%