Pharmacokinetic Drug–Drug Interactions and Herb–Drug Interactions

Choi, Min‐Koo; Song, Im‐Sook

doi:10.3390/pharmaceutics13050610

Cited by 11 publications

(9 citation statements)

References 18 publications

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“…The pharmacokinetic parameters of drugs in HDIs change, and these values can be measured to describe the variations in the ADME of drugs. The most common mechanism underlying pharmacokinetic interactions is the drug-mediated inhibition and induction of drugmetabolizing CYP isozymes (4,38). Therefore, in vitro studies on the inhibition or induction of the expression and activity of the CYP family of enzymes can be conducted to assess potential drug interactions (1,3,38).…”

Section: Discussionmentioning

confidence: 99%

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Potential pharmacokinetic and pharmacodynamic herb-drug interactions of Andrographis paniculata (Burm. f.) and andrographolide: A systematic review

Sundhani

Lukitaningsih

Nurrochmad

et al. 2022

J Herbmed Pharmacol

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Introduction: Herb–drug interactions (HDIs) in pharmacokinetics and pharmacodynamics can occur when natural compounds are used in combination with drugs. This study aimed to review the potential interaction of Andrographis paniculata (Burm. f.) extract (APE) and its primary compound andrographolide (AND) with several drugs exhibiting various pharmacological activities.Methods: In this systematic review, articles were collected from international databases such as PubMed, Science Direct, Springer Link, and Scopus until August 2021. The following keywords were used: Andrographis paniculata, andrographolide, HDI, drug interaction, pharmacokinetics, and pharmacology. This review was written in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), SYRCLE’s risk of bias (RoB) tool for animal intervention studies, and Cochrane RoB 2 tool to analyze the RoB for qualitative assessment.Results: Twelve articles were included in accordance with the inclusion and exclusion criteria of this study. Five studies explored the potential of HDIs for combining APE with drugs and AND with theophylline, etoricoxib, nabumetone, naproxen, and tolbutamide. Five studies focused on AND in combination with aminophylline and doxofylline, meloxicam, glyburide, glimepiride, metformin, and warfarin. Two studies tested the combination of APE with gliclazide and midazolam. The HDI mechanism involving the inhibition or induction of cytochrome P450 enzyme expression was dominant in influencing the drug’s pharmacokinetic profile. Pharmacological studies on the combination of several drugs, particularly anti-inflammatory and antidiabetic drugs, showed a synergistic activity.Conclusion: APE and AND have potential pharmacokinetic and pharmacodynamic HDIs with various drugs. This study can be used as a therapeutic consideration in clinical aspects related to the possibility of HDIs of A. paniculata (Burm. f.).

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Section: Discussionmentioning

confidence: 99%

“…The type and composition of herbal medicines commonly used by patients are also poorly described (3). The most widely reported cases of the emergence of HDIs today are the modulation of herbal medicinal components in the drug metabolism system involving cytochrome P450 (CYP)-metabolizing enzymes (4).…”

Section: Introductionmentioning

confidence: 99%

Potential pharmacokinetic and pharmacodynamic herb-drug interactions of Andrographis paniculata (Burm. f.) and andrographolide: A systematic review

Sundhani

Lukitaningsih

Nurrochmad

et al. 2022

J Herbmed Pharmacol

View full text Add to dashboard Cite

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“…Hence, the translation of the in vitro data to the clinical situation is difficult, but an understanding of the underlying mechanism will at least enable us to predict what might happen if we use cannabis products with concomitant anticancer therapy and thus to better perform a risk–benefit assessment of such combined treatment. Clinical evidence for drug–cannabis interactions, however, is largely lacking so far [ 77 , 121 , 122 ].…”

Section: Clinical Aspects Of Cannabis Productsmentioning

confidence: 99%

Potential, Limitations and Risks of Cannabis-Derived Products in Cancer Treatment

Woerdenbag

Olinga

Kok

et al. 2023

Cancers

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The application of cannabis products in oncology receives interest, especially from patients. Despite the plethora of research data available, the added value in curative or palliative cancer care and the possible risks involved are insufficiently proven and therefore a matter of debate. We aim to give a recommendation on the position of cannabis products in clinical oncology by assessing recent literature. Various types of cannabis products, characteristics, quality and pharmacology are discussed. Standardisation is essential for reliable and reproducible quality. The oromucosal/sublingual route of administration is preferred over inhalation and drinking tea. Cannabinoids may inhibit efflux transporters and drug-metabolising enzymes, possibly inducing pharmacokinetic interactions with anticancer drugs being substrates for these proteins. This may enhance the cytostatic effect and/or drug-related adverse effects. Reversely, it may enable dose reduction. Similar interactions are likely with drugs used for symptom management treating pain, nausea, vomiting and anorexia. Cannabis products are usually well tolerated and may improve the quality of life of patients with cancer (although not unambiguously proven). The combination with immunotherapy seems undesirable because of the immunosuppressive action of cannabinoids. Further clinical research is warranted to scientifically support (refraining from) using cannabis products in patients with cancer.

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“…It may be food–drug interaction or drug–drug interaction. The pharmacological response may alleviate, lessen or induce side effects [ 182 , 183 ]. Garlic (alicin) exhibits a hypotensive property and a hypocholesterolemic effect, acts as an anti-inflammatory agent and possess anti-bacterial as well as anti-fungal properties.…”

Section: Formulation Challengesmentioning

confidence: 99%

A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

et al. 2022

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Nutraceuticals are the nourishing components (hybrid of nutrition and pharmaceuticals) that are biologically active and possess capability for maintaining optimal health and benefits. These products play a significant role in human health care and its endurance, most importantly for the future therapeutic development. Nutraceuticals have received recognition due to their nutritional benefits along with therapeutic effects and safety profile. Nutraceuticals are globally growing in the field of services such as health care promotion, disease reduction, etc. Various drug nutraceutical interactions have also been elaborated with various examples in this review. Several patents on nutraceuticals in agricultural applications and in various diseases have been stated in the last section of review, which confirms the exponential growth of nutraceuticals’ market value. Nutraceuticals have been used not only for nutrition but also as a support therapy for the prevention and treatment of various diseases, such as to reduce side effects of cancer chemotherapy and radiotherapy. Diverse novel nanoformulation approaches tend to overcome challenges involved in formulation development of nutraceuticals. Prior information on various interactions with drugs may help in preventing any deleterious effects of nutraceuticals products. Nanotechnology also leads to the generation of micronized dietary products and other nutraceutical supplements with improved health benefits. In this review article, the latest key findings (clinical studies) on nutraceuticals that show the therapeutic action of nutraceutical’s bioactive molecules on various diseases have also been discussed.

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Pharmacokinetic Drug–Drug Interactions and Herb–Drug Interactions

Abstract: Due to the growing use of herbal supplementation—ease of taking herbal supplements with therapeutics drugs (i [...]

Cited by 11 publications

References 18 publications

Potential pharmacokinetic and pharmacodynamic herb-drug interactions of Andrographis paniculata (Burm. f.) and andrographolide: A systematic review

Potential pharmacokinetic and pharmacodynamic herb-drug interactions of Andrographis paniculata (Burm. f.) and andrographolide: A systematic review

Potential, Limitations and Risks of Cannabis-Derived Products in Cancer Treatment

A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

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