2018
DOI: 10.1002/cpdd.433
|View full text |Cite
|
Sign up to set email alerts
|

Pharmacokinetic Drug Interaction Study of Bazedoxifene and Ibuprofen

Abstract: The purpose of this article was to evaluate the potential for a pharmacokinetic interaction between bazedoxifene and ibuprofen. In a randomized crossover study, 12 healthy postmenopausal women (aged 45-65 years) received either a single oral dose of ibuprofen (600-mg tablet), bazedoxifene (20-mg capsule), or both ibuprofen and bazedoxifene during the 3 treatment periods. Serial blood samples were collected for pharmacokinetic analyses. There was no relationship between the UGT1A1 genotype and bazedoxifene clea… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
6
0

Year Published

2018
2018
2023
2023

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(6 citation statements)
references
References 25 publications
0
6
0
Order By: Relevance
“…The pharmacokinetics of BZA have been described in several studies of healthy postmenopausal women . The absolute bioavailability of BZA is approximately 6% .…”
mentioning
confidence: 99%
See 4 more Smart Citations
“…The pharmacokinetics of BZA have been described in several studies of healthy postmenopausal women . The absolute bioavailability of BZA is approximately 6% .…”
mentioning
confidence: 99%
“…The absolute bioavailability of BZA is approximately 6% . The time to maximum plasma concentration (t max ) for BZA 20 to 40 mg is about 1 to 3 hours, reaching a steady state within approximately 7 days . The average half‐life (t ½ ) for BZA is approximately 25 to 30 hours .…”
mentioning
confidence: 99%
See 3 more Smart Citations