Pharmacokinetic interaction of some antitubercular drugs with caraway: implications in the enhancement of drug bioavailability

Abstract

<jats:p> This study deals with the pharmacokinetic interaction of selected anti-TB drugs with a natural product (CC-1a) derived from caraway ( Carum carvi, L.) seed. CC-1a, chemically standardized butanolic fraction, enhanced the plasma levels of rifampicin, pyrazinamide, and isoniazid in Wistar rat, resulting in increased bioavailability indices (C<jats:sub>max</jats:sub> and AUC) of the drugs. Moreover, a 40% reduced dose regimen of these drugs, which additionally contained CC-1a, was equivalent in terms of C<jats:sub>max</jats:sub> and AUC to a normal dose regimen. A permeation-enhancing property of CC-1a across small intestinal absorptive surface was found to be a contributing factor in its bioavailability enhancing profile. </jats:p>

Cuminum cyminum and Carum carvi: An update

“…In recent studies carried out in the author's laboratory,[146147] a significant pharmacokinetic interaction of some herbal products from cumin and caraway with anti-tubercular drugs has been revealed. An aqueous extract derived from cumin seeds produced a significant enhancement of rifampicin levels in rat plasma.…”

“…The altered bioavailability profile of anti-TB drugs could be attributed to a permeation enhancing effect of cumin and caraway. [146147]…”

Effect of Carum carvi, a herbal bioenhancer on pharmacokinetics of antitubercular drugs: A study in healthy human volunteers

“…6007; Concept Pharmaceuticals, Mumbai, India) and Capsule containing C. carvi extract (100 mg) was supplied by Indian Institute of Integrative Medicine (IIIM), Jammu. The preparation and standardization of test material (extraction of C. carvi ) was done at IIIM, Jammu, as per the method described and used by Sachin et al ,[11] in their animal study evaluating pharmacokinetic interaction of some antitubercular drugs with caraway seeds.…”

“…[8] Carum carvi is one such herbal bioenhancer that has been extensively studied along with antibiotics, antifungals, antivirals, anticancer, anti-inflammatory, antitubercular, antihistaminics. [9] Although, a few recent studies have proved the bioenhancing property of C. carvi with antitubercular drugs in animals,[1011] to the best of our knowledge there is no study evaluating its bioenhancing property in humans. Thus, the present study was undertaken to evaluate the effect of C. carvi extract, a herbal bioenhancer on pharmacokinetics of antitubercular drugs in humans.…”

Subchronic and Chronic Toxicities of African Medicinal Plants

“…Also, a significant pharmacokinetic interaction of some herbal products from cumin and caraway with antitubercular drugs has been reported. An aqueous extract derived from cumin seeds produced a significant enhancement of rifampicin levels in rat plasma leading to exaggerated toxicity of rifampicin [140].…”