Pharmacokinetic interactions of ceftazidime, imipenem and aztreonam with amikacin in healthy volunteers

Efficacy of imipenem therapy for Nocardia actinomycetomas refractory to sulfonamides

“…Our sample size is too small to enable us to compare the relative merits of imipenem monotherapy versus imipenem and amikacin combination therapy. However, pharmacokinetic studies demonstrate that coadministration of imipenem and amikacin produces a higher concentration of imipenem than imipenem monotherapy, 28 and therefore we advocate combination therapy if tolerated. This study illustrates the marked clinical differences between patients who respond to and those who fail on sulfonamide therapy, and suggests that the use of sulfonamides as the only class of antibiotics should be for limited disease of comparatively short duration at low-risk sites for visceral dissemination.…”

In vitro synergism of β-lactams with ciprofloxacin and moxifloxacin against genetically distinct multidrug-resistant isolates of Pseudomonas aeruginosa

“…The final concentrations were 16 g/mL for imipenem, meropenem and ceftazidime and 2 g/mL for ciprofloxacin and moxifloxacin. The latter concentrations reflected the mean serum levels of these antimicrobials following administration of a conventional dose [9][10][11][12][13]. Time-kill assays for isolates demonstrating synergism with certain combination of antimicrobials were repeated to assess for between-day reproducibility.…”

“…Time-kill assays for isolates demonstrating synergism with certain combination of antimicrobials were repeated to assess for between-day reproducibility. For the same combinations, time-kill assays were repeated using concentrations of antimicrobials close to their maximum serum levels, which are 25 g/mL for imipenem and meropenem [9,14], 40 g/mL for ceftazidime [9] and 3 g/mL for ciprofloxacin and moxifloxacin [15,16]. One growth control was applied.…”

Comparison of HPLC and UV Spectrophotometric Methods for the Determination of Cefaclor Monohydrate in Pharmaceutical Dosages

“…Several analytical procedures are available in literature for the analysis of antimicrobial. These methods are spectrophotometry (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13), high performance liquid chromatography (14)(15)(16)(17)(18)(19), capillary electrophoresis (20), fluorimetry (21)(22)(23)(24), polarography (25)(26)(27)(28)(29),titrimetry (30), and bioassay (31)(32). Spectrophotometric assay for determination of other cephalosporins as ceftazidime has been described (33) but no method for Cefaclor monohydrate had been previously described.…”